Institut Pasteur

Medical Research Council

Université Pierre Et Marie Curie (paris Vi)

Universite De Berne

Assistance Publique

Nadine Honore

Stewart T Cole

Douglas B Young

Ying Zhang

Beate Heym

Thomas Bodmer

Amalio Telenti

Roland Brosch

Laleh Majlessi

Matthias Groschel

Roxane Simeone

Fadel Sayes

Martin Sapp

Wolfgang Philipp

Recombinant strains ofbacille Calmette-Guerin (BCG) comprising a heterologous nucleic acid sequence of() are provided. In some embodiments the heterologous nucleic acid sequence ofcomprises a plurality of open reading frames, wherein the plurality of open reading frames comprise open reading frames that encode proteins each at least 95% homologous to the() proteins MMAR5445, MMAR5446, MMAR5447, MMAR5448, MMAR5449, MMAR5450, MMAR5451, MMAR5452, MMAR5453, and MMAR5455. In some embodiments the plurality of open reading frames further comprise an open reading frame that encodes a protein at least 95% homologous to theproteins MMAR5443, MMAR5444, and MMAR5457. In some embodiments the plurality of open reading frames further comprise open reading frames that encode proteins at least 95% homologous to theproteins MMAR5429, MMAR5430, MMAR5431, MMAR5432, MMAR5433, MMAR5434, MMAR5435, MMAR5436, MMAR5437, MMAR5438, MMAR5439, MMAR5440, MMAR5441, MMAR5442, MMAR5454, MMAR5456, MMAR5458, MMAR5459, MMAR5460, and MMAR5461. Pharmaceutical compositions, kits, methods of inducing an immune response againstin a subject, and methods of treating aninfection in a subject are also provided, among other things.

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A nucleotide sequence encoding a katG/lacZ fusion protein is useful for assaying the enzymatic activity of the katG gene product. A process of selecting a compound that is toxic against an isoniazid-resistant mycobaterial strain comprises incubating a catalase peroxidase enzyme with an isoniazid to produce a compound that restores isoniazid susceptability to the isoniazid-resistant mycobaterial strain.

Rapid detection of antibiotic resistance in mycobacterium tuberculosis

DNA sequences of the papillomavirus HPV42 for use in diagnosis

Growing community of inventors

Colombes, France

Nadine Honore