Rush University Medical Center

University of Texas System

Orthopedic Analysis LLC

Nadim James Hallab

Joshua J Jacobs

Shalini Prasad

Markus A Wimmer

Lauryn A Samelko

Mathew T Mathew

Various aspects of the present invention provide an apparatus and a method of removing an orthopedic implant from a patient. In one embodiment, the method includes cycling the temperature of at least a portion of the orthopedic implant between a first temperature and a second temperature that differs from the first temperature. In one embodiment, the first temperature is above 0&#xb0; C. and the second temperature is below 0&#xb0; C. The temperature cycling causes a thermal expansion differential between at least a portion of the orthopedic implant and material in a region contacting the orthopedic implant. In one embodiment, the thermal expansion differential is of an extent sufficient to cause physical separation of at least a portion of the surface of the orthopedic implant from material contacting the surface of the orthopedic implant.

Implant removal devices and methods of use thereof

Described herein is a method for treating or prophylaxis of adverse immune reaction to metal debris, metal induced delayed type hypersensitivity (DTH), or inflammatory osteolysis by attenuating the inflammatory response. In one aspect, the method involves inhibiting the nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome/caspase-1 pathway or neutralizing or blocking the activity of interleukin 17 (IL-17), IL-17 receptor (IL-17R), IL-1R, IL-1&#x3b2;, IL-18, IL-21, IL-23 with anti-IL-17, anti-IL-17A, anti-IL-17F, anti-IL-17A/F, anti-IL-1, anti-IL-1&#x3b2;, anti-IL-18, anti-IL-21, anti-IL-23, anti-IL-1R, soluble IL-17 receptors, soluble IL-1 receptors, soluble IL-18 receptors, soluble IL-21 receptors, IL-17 receptor inhibitors, IL-1 receptor inhibitors, IL-18 receptor inhibitors, IL-21 receptor inhibitors, IL-23 receptor inhibitors, blocking agents, inflammasome inhibitors, or combinations thereof.

Treatment for adverse immune reaction to metal implant debris

One aspect of the invention provides a method of determining metal ion levels in the patents due to corrosion and wear processes of the metallic implant in a human or veterinary patient. One embodiment provides a cost effective and patient driven early diagnostic method which has a potential application in orthopedics and dentistry. In one embodiment, the method includes the use of an electrochemical biosensor to detect metal ions or particles in a sample taken from a patient having a metallic implant.

Metal-ion electrochemical biosensor and use thereof

A system for maintaining a biological sample within a desired temperature range during transport. Preferably, the system includes a container defining an inner chamber; a specimen receptacle for housing a biological sample, wherein the specimen receptacle is configured to be placed within the inner chamber of the container; a heat source configured to be placed within the inner chamber of the container; and a heat sink. The heat sink is configured to be positioned between the heat source and the specimen receptacle, thereby preventing direct heat transfer between the heart source and the specimen receptacle. Certain embodiments also relate to a method for maintaining biological samples within a desired temperature range during transport, using at least some of the system components. Preferably, the components used with the method are configured to maintain the sample at a temperature greater than 0&#xb0; C. and less than approximately 37&#xb0; C. during shipping.

Growing community of inventors

Oak Park, IL, United States of America

Nadim James Hallab