Phylogica Limited

The Mccomb Foundation, Inc.

Nadia Milech

Paul Michael Watt

Mark Fear

Richard Hopkins

The present invention provides a topical composition comprising (i) an amount of an AP-1 signaling inhibitor sufficient to reduce, delay or prevent apoptosis and/or necrosis induced by dermal wounding and/or to induce and/or enhance proliferation of a cell; and (ii) a suitable carrier or excipient e.g., a topical carrier or excipient or other carrier or excipient for dermal application. For example, the AP-1 signaling inhibitor is a peptide analog comprising the sequence set forth in SEQ ID NO: 104. The present invention also provides a method of treating a dermal wound comprising topically administering said topical composition to a subject suffering from a dermal wound.

Compositions and uses thereof for the treatment of wounds

The present invention provides AP-1 signaling inhibitory peptides of SEQ ID NOS:54-57, compositions of the peptides, and methods of treatment of neurological disorders by administration of the peptide(s) or compositions.

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Daglish, Australia

Nadia Milech