Florida Atlantic University

Nadia K Sial

Salvatore Donato Lepore

Kenneth Dawson-Scully

Elijah J St Germain

Samantha L Maki

Wesley L Bollinger

Neuroprotective compounds for reducing neurological damage due to cellular stress in an individual are of Formula 1: or an enantiomer, diastereomer, racemic mixture or a pharmaceutically acceptable salt thereof, wherein: Ar=aryl; Y=aryl substituent (ortho, meta, or para) selected from the group consisting of: alkyl, alkyloxy, alkylamino, RRN, and halo; X&#x2550;O, N, or S; R&#x2550;H, alkyl, aryl, OH, alkyloxy, aryloxy, NH, alkylamino, RRN, or arylamino; Rand R=alkylcarbonyl, arylcarbonyl, alkyl, or H, individually; R=arylCH&#x2550;CH, alkylCH&#x2550;CH, alkyl; R&#x2550;H, alkyl, or aryl; and Rand R=alkyl, individually. Methods of reducing neurological damage due to cellular stress in an individual include administering to the individual during or after the cellular stress a neuroprotective compound of Formula I in a therapeutically effective amount to restore synaptic function during or after the cellular stress.

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Boca Raton, FL, United States of America

Nadia K Sial