The University of Melbourne

Csl Limited

Oral Health Australia Pty Ltd

Other

Nada Slakeski

Eric Charles Reynolds

Neil Martin O'Brien-Simpson

Neil Martin O'Brien Simpson

Keith J Cross

Ian George Barr

Chao Guang Chen

Guang Gao Chen

George Ian Barr

Anne Hendtlass

Peter Singh Bhogal

Neil Martin O'brien Simpson

Neil Martin O'brien-Simpson

Neil Martin O'BRIEN Simpson

Disclosed areantibodies raised against a chimeric or fusion protein, wherein the chimeric or fusion protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein (A) the first peptide comprises a region of atrypsin-like enzyme and (B) the second peptide or polypeptide comprises an adhesin domain of

Antibodies for prevention, treatment and diagnosis ofinfection

Disclosed are methods related to the generation and use of cellular and humoral responses for the prevention and treatment ofrelated conditions and diseases, such as methods of preparingantibodies, comprising immunizing a non-human animal with a chimeric or fusion protein, wherein the protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein (A) the first peptide comprises a region of atrypsin-like enzyme and (B) the second peptide or polypeptide comprises an adhesin domain of

Methods of preparingantibodies

The invention relates to generation and use of cellular and humoral responses for the prevention and treatment ofrelated conditions and diseases.

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The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacteriumassociated with periodontal disease.

The present invention provides an antigenic composition, the composition comprising at least one recombinant protein. The recombinant protein comprises at least one epitope. The epitope is reactive with an antibody which is reactive with a polypeptide having the sequence set out in SEQ. ID. NO. 3 or SEQ. ID. NO. 5. The invention also provides methods and compositions for the production of the recombinant protein. Also provided are methods for the diagnosis, treatment and prevention ofinfection.

The present invention provides a composition for use in raising an immune response directed against The composition includes a suitable adjuvant and/or acceptable carrier and one substantially purified immunogen. The immunogen is selected from the group consisting of Antigen 1, Antigen 2, Antigen 3, Antigen 4 and epitope containing fragments thereof, in which: Antigen 1 is an antigen of and has an internal amino acid sequence:DLENKGEATLLVTFGSSYKAPRETYAKIEKTFAAAYPDQR; Antigen 2 is an antigen of and has an internal amino acid sequence: DNPDENPLEGDITQTHTEKYVLAED; Antigen 3 is an antigen of and has an internal amino acid sequence: DVLLLDVTPLSLGIETMGGVMTYLIDANTTIPKLK; Antigen 4 is an antigen of and has an internal amino acid sequence: VYNASISAVGNTSAIDPVVQIIHHN.

Porphyromonas gingivalis antigens for the diagnosis and treatment of periodontitis

This invention relates to the PrtR-PrtK cell surface protein of in particular a multimeric cell associated protein complex comprising the PrtR and PrtK proteins. There is provided a substantially purified antigenic complex for use in raising an antibody response directed against The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain. The complex has a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with

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Kew, Australia

Nada Slakeski