Reg Life Sciences, LLC

Genomatica, Inc.

Ls9, Inc.

Na Trinh

Andreas W Schirmer

Mathew A Rude

Jacob Gano

Zhihao Hu

Louis G Hom

Murtaza F Alibhai

Eli S Groban

Vikranth Arlagadda

Elizabeth J Clarke

Murtaza Alibhai

The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells. The disclosure further relates to methods of making and using such AAR variants for the production of fatty alcohol compositions having particular characteristics.

Acyl-ACP reductase with improved properties

The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.

Methods and compositions related to thioesterase enzymes

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South San Francisco, CA, United States of America

Na Trinh