Siga Technologies Inc.

Hewlett-packard Development Company, L.P.

N K Peter Samuel

Dennis E Hruby

Shanthakumar R Tyavanagimatt

Ying Tan

William C Weimers

Melialani A C L S Anderson

Gopi Krishna Kasi

Tove C Bolken

Joseph Paz

Matthew Reeves

Steven Priebe

David Ridgway Otis, Jr

Christopher Vitello

Tove′ C Bolken

Joseph W Dody

Casey Timon Miller

Gerald F Meehan

Shantakumar R Tyavanagimatt

The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.

ST-246 liquid formulations and methods

Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.

Rehydration of micronized tecovirimat monohydrate

Rehydration of micronized tecovirmimat monohydrate

Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide.

Amorphous Tecovirimat preparation

Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide.

Amorphous tecovirimat preparation

A volumetric fluid dispensing device can include a fluid reservoir having at least one flexible wall and a dispensing reservoir oriented above the fluid reservoir. The dispensing reservoir can have an overflow return fluidly connected to the fluid reservoir such that the dispensing reservoir holds a measured volume of fluid. A reservoir conduit can be fluidly connected to the fluid reservoir and the dispensing reservoir to allow excess fluid to return from the overflow to the fluid reservoir. A dispensing conduit can also be fluidly connected to the dispensing reservoir to allow fluid to exit the dispensing reservoir. A mechanical wall actuator can be operatively associated with the walls for controllably flexing at least a portion of the walls sufficient to force fluid from the fluid reservoir to the dispensing reservoir via the reservoir conduit.

Volumetric is fluid dispensing devices, systems, and methods

Growing community of inventors

Corvallis, OR, United States of America

N K Peter Samuel