Massachusetts Institute of Technology

N Catherine Hogan

Ian W Hunter

Andrew James Taberner

Yi Heng Chen

Brian D Hemond

Dawn M Wendell

Lynette A Jones

Andrew J Taberner

The present invention relates to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

Bi-directional motion of a Lorentz-force actuated needle-free injector (NFI)

The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

Bi-directional motion of a lorentz-force actuated needle-free injector (NFI)

A method for testing the effect of a skin care product includes measuring a mechanical property of skin tissue using nonlinear stochastic system identification, applying the product to the skin, repeating the measurement of the mechanical property after the application of the product, and comparing the before and after measurements to quantify the effect of the product. Measuring the mechanical property of the skin can include placing a probe against a surface of the skin, perturbing the skin with the probe using a stochastic sequence, and measuring the response of the skin to the perturbation. Perturbing the skin can include indenting the skin with the probe, extending the skin with the probe, and sliding the probe across the skin surface. The mechanical property may be indicative of skin compliance, skin elasticity, skin stiffness, or skin damping. The mechanical property can be dependent on perturbation depth and may be measured at a plurality of anatomical locations.

Identification techniques and device for testing the efficacy of beauty care products and cosmetics

The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber. A bi-directional electromagnetic actuator is in communication with the chamber. The actuator, when activated, generates a pressure within the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.

A method for transferring a solid body across a surface of a biological body includes (i) applying an electrical input to a controllable electromagnetic actuator; (ii) producing with the electromagnetic actuator a mechanical force corresponding to the electrical input; and (iii) applying the mechanical force to a reservoir coupled at one end to a nozzle, the mechanical force producing a pressure within the reservoir, a magnitude of the pressure varying with the mechanical force and causing ejection of a fluid from the reservoir to drive the solid body into the biological body. A method for delivering a substance to a target body includes (i) positioning a needle-free injector proximate to a surface of the target body; (ii) injecting the substance into the target body; and (iii) while injecting, moving the needle-free injector along the surface, thereby sweeping the surface.

Delivery of a solid body and/or a fluid using a linear Lorentz-force actuated needle-free jet injection system

A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.

Injection methods using a servo-controlled needle-free injector

The present invention relate to a method and corresponding apparatus for extraction of a sample from a sample source. A fluid is injected into the sample source and the sample source is vibrated. A sample is withdrawn from the vibrated sample source and the sample source is evaluated by measuring one or more identifying parameters in the withdrawn sample.

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Boston, MA, United States of America

N Catherine Hogan