Hovione Scientia Limited

Hovione International Limited

Hovione Holding Limited

Márcio Temtem

Peter Villax

Luis Sobral

Tiago Fonseca

João Vicente

Constança Cacela

Iris Duarte

Eunice Costa

Filipa Santos

João Vincente

Hugo Lisboa

Luis Padrela

Maria José Pereira

A complexation process between a cyclodextrin and active pharmaceutical ingredients is disclosed, and comprises a process for preparing a complex of at least one cyclodextrin and at least one active pharmaceutical ingredient comprising the steps of The described process has high throughput with higher yields of complexation in less time than prior art methods. The complexes obtained by the invention are characterized by having enhanced dissolution and/or bioavailability of the active pharmaceutical ingredient in body fluids.

Continuous complexation of active pharmaceutical ingredients

The present invention discloses a method to continuously manufacture micro- and/or nanoparticles of single component particles or multi-component particles such as particulate amorphous solid dispersions or particulate co-crystals. The continuous method comprises the steps of 1. preparing a first solution comprising at least one component and at least one solvent and a second solution comprising at least one anti-solvent of the at least one component comprised in the first solution, 2. mixing said first solution and said second solution by means of microfluidization to produce a suspension by precipitation or co-precipitation, 3. feeding said suspension to a filtration system to obtain a concentrate stream, 4. feeding said concentrate stream to a spray dryer, 5. atomizing said concentrate stream using at least one atomization nozzle, 6. drying said atomized concentrate stream to obtain particles, and 7. collecting said particles. Single component particles or multi-component particles, particulate amorphous solid dispersions, particulate co-crystals and pharmaceutical compositions are also disclosed.

Continuous production of particles

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Quinta do Conde, Portugal

Márcio Temtem