Korea Institute of Science and Technology

Myung-Suk Chun

Jae-Jin Kim

Sang Yup Lee

Ji-Young Lee

Jae Hun Kim

Hyoung-Juhn Kim

Suk Woo Nam

Young Tae Byun

Sun Mi Lee

In Kyu Song

Sang-Yup Lee

Dae Ki Choi

Min Suk Shim

Nak Won Choi

Kwang Seok Kim

Chansung Park

Byoungjin Chun

Tae Ha Kim

Heesoo Jeon

Provided is an apparatus for cell particle sorting based on microfluidic-chip flow, by using a design in which Dean flow focusing occurring in a spiral channel and hydrodynamic filtration are coupled. The apparatus comprises a first substrate including a spiral channel having an inner surface and an outer surface based on a radius of curvature, a sample solution inlet, a medium inlet, and a spiral inner-outlet and a spiral outer-outlet both for discharging the particles, and a second substrate including a main channel in which the sample solution discharged from the first substrate and passing through an inter-substrate way flows and a cut-off width Wis set, a side channel allowing a medium introduced into the medium inlet to flow to focus the sample solution on a sidewall of the main channel, a plurality of branch channels connected to the sidewall of main channel and configured to receive the particles from the main channel, a main channel outlet, and at least one branch channel outlet.

Apparatus and method for cell particle sorting based on microfluidic-chip flows

Disclosed herein is a method and an apparatus using microfluidic channel array for converting mechanical energy into electric energy by streaming potential and streaming current caused when the electrolyte liquid flows in a charged surface due to a pressure drop. The present invention relates to a method and an apparatus for designing channels with hierarchical structure in which a primary multi-channel is provided by radially arranging one or more unit channels, and each of the unit channels includes an inflow channel, an outflow channel, and a secondary multi-channel provided by arranging one or more channels in parallel, thereby improving output power and flow stability.

Method and apparatus for energy conversion using microfluidic channel array with hierarchical structure

An apparatus for generating pulsatile flows includes a liquid vessel capable of containing a liquid, a plurality of revolving mechanisms associated with each other, and a microchannel supplied with a liquid from the liquid vessel. As the plurality of revolving mechanisms rotate, a periodically changing pressure difference occurs between the liquid vessel and the microchannel, thereby implementing a pulsatile flow having a wave functional form in the microchannel. By applying the hydraulic head difference and controlling revolution of the revolving mechanisms based on Fourier cosine series, a minute and precise pulsatile flow of a wave functional form may be implemented by means of simple configuration and fabrication, which may not easily obtained by a conventional pump.

Apparatus and method for generating wave functional pulsatile microflows by applying Fourier cosine series and hydraulic head difference

Embodiments of the present invention may provide a microchip applicable to an electrophoresis employing UV detection and a method of manufacturing the same. The microchip of the present invention has a glass channel plate, which is formed on an upper surface thereof with a loading channel and a separation channel and is provided on the upper surface thereof with an optical slit layer made of silicon except the channel region, and a glass reservoir plate, which is formed with sample solution reservoirs and buffer solution reservoirs. The loading channel and the separation channel are formed on the channel plate by deep reactive ion etching. The sample solution reservoirs and the buffer solution reservoirs are formed in the reservoir plate by sand blasting. The channel plate and the reservoir plate are combined by anodic bonding the optical slit layer and the reservoir plate. Electrodes for sample and electrodes for buffer are deposited by sputtering Pt with a shadow mask after anodic bonding.

Glass electrophoresis microchip and method of manufacturing the same by MEMS fabrication

Disclosed is a micro power cell capable of being applied as an energy source and utilizing a streaming potential phenomenon occurring in accordance with an electrokinetic principle when an electrolyte aqueous solution flows in the microchannels piled up in several layers. The streaming potential cell consists of a PDMS microfluidic-chip fabricated by MEMS process as well as micromachining technology. The microfluidic-chip is formed with multi microchannels radially arranged in parallel with each other around a center of a disk at a regular interval. The disk type multi microchannel can achieve uniform inflow and outflow effects. According to the invention, there is provided a cell device comprising a pile-up chip having a number of disk type microfluidic-chips with the optimal structure of flow-in and flow-out of a fluid, a distributor, a collector, an electrode insertion part, etc.

Electrokinetic micro power cell using pile-up disk type microfluidic-chip with multi-channel

The invention relates to a new micro power cell applying the microfluidic-chip with multi-channel type. The streaming potential is the main thrust, which is created by Helmholtz-Smoluchowski's electrokinetic principle when electrolytic solution flows through a microchannel. The microfluidic-chip comprises an inflow port, a distributor, a multi-channel, a collector, an outflow port, and a pair of electrodes. The present invention could be applied to a new power source of clean energy.

Electrokinetic micro power cell using microfluidic-chip with multi-channel type

The present invention relates to a method for preparing a heteropolyacid catalyst and method for preparing methacrylic acid using thereof. More particularly, the present invention relates to a method for preparing heteropolyacid catalyst, which is produced by the recrystallization of a heteropolyacid and/or its salt dissolved in a basic organic solvent and heat-treatment, and further to a method for preparing metachrylic acid using thereof, wherein the use of the heteropolyacid catalyst increases the activity of oxidation reaction induced by the modified electronic properties of heteropolyanions and provides high efficiency production of methacrylic acid from methacrolein, since the basic property of solvent inhibits peculiar acidic property of heteropolyacid.

Method for preparing a heteropolyacid catalyst from basic solvent treatments and method for preparing methacrylic acid using thererof

The present invention relates to an apparatus for monitoring the progress of membrane fouling that occurs on pores as well as on the surface of a membrane by means of variations of zeta potential (&#x3b6;) of a hollow-fiber membrane according to time passage of filtration of a suspension, wherein colloid particles, biopolymers and other inorganic particles are dispersed, and the method thereof. Moreover, the present invention also relates to a method to identify the effect of concentration polarization layer and cake layer which can vary according to the axial position of a hollow-fiber and the developing progress of a membrane fouling by measuring the position-dependent zeta potential of the hollow-fiber membrane.

Equipment of local streaming potential measurement for monitoring the fouling process in hollow-fiber filtrations of nano-colloidal suspension

A particle diffusion coefficient measuring device is provided with a hollow-fiber including micropores on its surface. The hollow-fiber provides a passage for particle suspension to transport through. The device is also provided with a fluid passage formed outside the hollow-fiber to communicate with the hollow-fiber via the micropores. The fluid passage provides a passage for an electrolyte solution to transport through in such a manner that the electrolyte solution is delivered to flow in the same direction as that of the particle suspension and is discharged from the fluid passage. The device detects a concentration change of the particles in the electrolyte solution discharged out of the fluid passage over a time change and calculates a particle diffusion coefficient by using the concentration change of the particles over the time change.

Device and method for measuring a diffusion coefficient of nano-particle fluid through hollow-fiber micropores

The present invention relates to an apparatus for monitoring the progress of membrane fouling that occurs on pores as well as on the surface of a membrane by means of variations of zeta potential (&zgr;) of a hollow-fiber membrane according to time passage of filtration of a suspension, wherein colloid particles, biopolymers and other inorganic particles are dispersed, and the method thereof. Moreover, the present invention also relates to a method to identify the effect of concentration polarization layer and cake layer which can vary according to the axial position of a hollow-fiber and the developing progress of a membrane fouling by measuring the position-dependent zeta potential of the hollow-fiber membrane.

Equipment and method of local streaming potential measurement for monitoring the process of membrane fouling in hollow-fiber membrane filtrations

A membrane filtration method and an apparatus for continuously monitoring the state of a membrane during the filtration, particularly for membrane fouling due to cake or gel layers of solutes developed on the surfaces of a filtered membrane, by estimating a membrane potential and a membrane solute rejection while making measurements of a set of physical properties of feed, variations of a streaming potential difference across pores of the membrane, variation in pressure differences between an upstream side and a downstream side of the membrane, and concentration differences between the feed and permeate filtered through the membrane.

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Seoul, South Korea

Myung-Suk Chun