Korea Institute of Science and Technology

Korea Research Institute of Bioscience and Biotechnology

Kyungpook National University Industry-academic Cooperation Foundation

Cj Cheiljedang Corporation

Myung-Sook Choi

Tae-Sook Jeong

Song-Hae Bok

Surk-Sik Moon

Yong-Kook Kwon

Ki-Hwan Bae

Yong-Bok Park

Eun-Sook Lee

Yang-Kyu Choi

Chul-Ho Lee

Byung-Hwa Hyun

Sae-Bom Lee

Young-Bae Park

Hyo-Soo Kim

Kwang-Hee Son

Byoung-Mog Kwon

Young-Kook Kim

Sung-Uk Kim

Ingyu Hwang

Doil Choi

Jung-Ah Ahn

Ho Yong Park

Byung-Tae Ahn

Ki Hun Park

Sung-Gyu Kim

Tae Sook Jeong

Dong-Ha Shin

Og-Sung Moon

Woo Song Lee

Jong-Min Han

Hyung-Jae Jeong

Han-Young Cho

Sang-Ku Lee

Ju-Ryong Kim

Jun-Sung Lee

Eun-Young Kwon

Hyeon-Seon Ji

Seong-Choon Choe

Ye Jin Kim

Ri Ryu

Hua Li

Eun-young Kwon

Youngji Han

Provided is a composition for preventing, improving or treating obesity, which includes aextract as an active ingredient and a method for preparing the extract with an improved anti-obesity effect. The extract shows an effect of inhibiting increases in body weight and fat mass caused by a high-fat diet for normalization, an increase in fasting blood glucose and a decrease in energy expenditure in a diet-induced obesity mouse model. Further, compared to an extract prepared by a conventional extraction method, theextract shows a more excellent effect of inhibiting increases in body weight and fat mass, fasting blood glucose, and blood lipid and adipokine contents in experiments, resulting in an excellent anti-obesity effect. Therefore, theextract prepared is expected to be useful for preventing obesity and treating obesity-related complications that can be caused by an increase in fat mass as well as obesity.

Pharmaceutical composition comprising an extract of platycodon grandiflorum and method for preventing or treating of obesity using the same

A composition for prevention or treatment of metabolic syndrome or for antioxidation includes black soybean leaf extracts and flavonol glycoside compounds isolated thereof as active ingredients. It has been confirmed that the black soybean leaf extracts and the flavonol glycoside compounds isolated thereof effectively inhibit &#x3b1;-glucosidase activity; LDL oxidation and DDP-4; have excellent DPPH radical scavenging activity; inhibitory activity of reactive oxygen species (ROS) accumulation; effectively promote insulin secretion; regulate the expression of major genes; have an excellent ability to reduce a waist/hip circumference ratio; decrease the concentrations of plasma free fatty acid and plasma triglyceride; increase the concentration of plasma HDL-cholesterol; decrease an atherogenic index; increase erythrocyte catalase, SOD and GR activities; decrease erythrocyte lipid peroxide TBARS; decrease the concentrations of inflammatory cytokines MCP-1 and PAI-1, and resistin; and increase the concentration of plasma adiponectin.

Composition for prevention or treatment of metabolic syndrome or for antioxidation containing black bean leaf extracts and flavonol glysosides isolated therefrom as active ingredients

The present invention relates to compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts ofleaves or fractions isolated from the same.

Compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of glycine max leaves or fractions isolated from the same as an active ingredient

0A method for treating or preventing an elevated blood lipid level-related disease in a mammal, which comprises administering thereto an effective amount of rutin, quercetin or a mixture thereof.

Method for preventing or treating elevated blood lipid level-related diseases by administering rutin and quercetin

A method for treating or preventing an elevated blood lipid level-related disease in a mammal, which comprises administering thereto an effective amount of rutin, quercetin or a mixture thereof.

The present invention relates to a spice composition comprising 1 to 30 % by weight of garlic, 10 to 50% by weight of onion, 0.2 to 10% by weight of ginger, 5 to 40% by weight of jujube, and 10 to 50% by weight of citrus peel or an extract thereof or 1 to 20% by weight of naringin or hesperidin.

Health-improving spice composition

Flavanone derivatives and composition for preventing or treating blood lipid level-related diseases comprising same

A method for treating or preventing an elevated blood lipid level-related disease such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and hepatic diseases in a mammal, which comprises administering thereto an effective amount of a cinnamic acid derivative of formula Ia or Ib, or a pharmaceutically acceptable salt thereof:

Method for preventing or treating elevated blood lipid level-related diseases by administering cinnamic acid derivatives

Methods for inhibiting the activity of acyl CoA-cholesterol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal comprise administering naringin or naringenin thereto.

Naringin and naringenin as inhibitors of acyl

A method for increasing the plasma high density lipoprotein(HDL) level in a mammal comprises administering a bioflavonoid of formula(I) or plant extract containing same thereto: ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5.sub.7 R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are each independently hydrogen; a hydroxy group; a C.sub.1-9 alkoxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkylcarbonyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.2-10 or C.sub.16-18 acyloxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen and nitro group; a rutinosyl group; or a rhaminosyl group; and

Bioflavonoids as plasma high density lipoprotein level increasing agent

A method for treating or preventing an elevated blood lipid level-related diseases such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and hepatic diseases in a mammal, which comprises administering thereto an effective amount of tannin, gallic acid or ellagic acid.

Method for preventing or treating elevated blood lipid level-related

A method for lowering the blood glucose level in a mammal comprises administering an effective amount of a hesperetin or naringenin bioflavonoid.

Method for lowering blood glucose level by the administration of

A method for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG--CoA) reductase in mammals is disclosed comprising administering naringin or naringenin thereto.

Naringin and naringenin as 3-hydroxy-3-methylglutaryl CoA(HMG-CoA)

A method for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises administering citrus peel extract thereto.

Citrus peel extract as 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase

A method for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises administering hesperidin or hesperetin thereto.

Hesperidin and hesperetin as 3-hydroxy-3-methylglutaryl CoA (HMG-CoA)

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Daegu, South Korea

Myung-Sook Choi