Dongkook Pharmaceutical Co., Ltd.

Other

Korea Institute of Science and Technology

Suheung Capsule Co., Ltd.

Myung K Kim

Sang Ki Rhee

Wan Soo Kim

Jin Kyu Park

Hak Ryol Kim

Won T Cho

T B Panichkina

A G Domracheva

L A Saburoba

L M Nobikoba

Y E Bartochevichi

Bong Hyun Chung

Eui Sung Choi

Jung Hoon Sohn

Deok Joong Youn

Hae Don Lee

Disclosed herein is a process for purifying hirudin from a solution containing hirudin and other substances, characterized in that the process comprises a step of subjecting the solution to a metal ion affinity chromatography wherein copper ion (Cu.sup.++) is used as a metal ion and a phosphate buffer is used as an eluent.

Purification process for hirudin using affinity chromatography

Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS(KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively.

Method for producing aclacinomycins A, B, Y using Strepomyces

Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS (KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively.

S. lavendofoliae DKRS cell culture producing anti-tumor aclacinomycins

A medicinal capsule comprising a cap member containing a first circumferential slot formed on the outer surface of the upper portion, at least one raised member formed on the inner surface of the cap, a body member containing a second circumferential slot formed on the outer surface of the upper portion thereof for slidably locking with the first circumferential slot of the cap member during final locking, and at least one connecting member formed on the outer surface of the second circumferential slot of the body member and extending internal to the body member for slidably locking with the raised member of the cap member, the raised member and the connecting member being dimensional relative to each other so as to form a space therebetween whereby when the cap member and body member are preliminarily locked prior to final locking, the capsule is not deformed.

Medicinal capsule

Growing community of inventors

Seoul, South Korea

Myung K Kim