Curacle Co., Ltd.

Korea Advanced Institute of Science and Technology

Gwangju Institute of Science and Technology

Kyungpook National University Industry-Academic Cooperation Foundation

Yonsei University

Myung-Hwa Kim

Sung Hwan Kim

Young-Guen Kwon

Chul Su Baek

Koo Hyeon Ahn

Jung-In Pyo

Jae-Han Jeon

In-Kyu Lee

Jin Hee Ahn

Haushabhau Shivaji Pagire

Hail Kim

Suvarna Haus-habhau Pagire

Ajin Lim

Ko Eun Shong

Haiying Zhang

Eun Jung Bae

Kun-Young Park

Kwang-eun Kim

Jaemyoung Suh

Jung-Ln Pyo

Minyoung Noh

Songyi Park

The present invention relates to a crystalline form of (E)-methyl 6-((3S,8S,9S,10R,13S,14S,17R)-3-(((5S,6R)-5-acetoxy-6-(acetoxytnethyl)-5,6-dihydro-2H-pyran-2-yl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10.11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-17-yl)hept-5-enoate and a blood vessel leak blocker comprising the same. The novel crystalline form has high purity, excellent stability, excellent long-term storage and pharmaceutical stability, and can be used as a vascular leakage blocker, so it is very advantageous in producing high-quality drug substances.

Crystalline form of vascular leakage blocker compound

The present invention relates to a preparation method of a novel vascular leakage blocker with a high yield. The preparation method is easy to react and more productive and economical than the conventional method by using an intermediate that can easily remove impurities generated during the reaction. In addition, the preparation method can produce a novel vascular leakage blocker with a high yield by using a new reagent that has not been previously used in the step of generating an isomer, and is very advantageous in producing a high-quality active pharmaceutical ingredient.

Preparation method of vascular leakage blockers with a high yield

The present invention relates to a novel tryptophan hydroxylase inhibitor and a pharmaceutical composition including same, wherein the novel tryptophan hydroxylase inhibitor has an excellent inhibitory effect on TPH1, and thus can be usefully used for the prevention or treatment of disorders, such as metabolic disorders, cancer, digestive or cardiovascular system disorders, related to TPH1 activity. In particular, the novel tryptophan hydroxylase inhibitor has an excellent treatment effect on inflammatory bowel disorders, and thus can be usefully used for the treatment of inflammatory bowel disorder.

Tryptophan hydroxylase inhibitor and pharmaceutical composition including same

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Seongnam-si, South Korea

Myung-Hwa Kim