Ajou University Industry-Academic Cooperation Foundation

Sungkyunkwan University

Invitroplant Co., Ltd.

Ministry of Agriculture Food and Rural Affairs Animal and Plant Quarantine Agency

Ministry for Food, Agriculture, Forestry and Fisheries, National Veterinary Research and Quarantive Service

Myung-Hee Kwon

Yong-sung Kim

Seung-Hyun Lee

Eun Jin Choi

Woo-Ram Lee

Young-Rim Kim

Yong-Sung Kim

Gun-Sup Lee

Jae Young Song

Chang-Han Lee

Jong-Nam Sohn

Yi-Jung Jung

Ki-Yoon Kim

Yu-Chul Chung

Eul-Yong Park

Hye-Kyung Shim

Jeong-Sun Kim

Tai-Hyun Kim

Suk-Chan Lee

Ji-Young Jang

Provided is an antiviral agent against animal viruses. The antiviral agent contains a protein or a nucleic acid sequence encoding the protein, as an active ingredient, the protein having binding ability and degrading ability to foreign nucleic acid chains invaded in an animal cell and that has no cytotoxicity to the animal cell itself. Also provided is an antiviral animal cell containing the protein according to the present invention, or the nucleic acid sequence encoding the protein. The antiviral agent and antiviral animal cell exhibit advantageous effects in that they selectively degrade foreign nucleic acid chains invaded in an animal cell and have no cytotoxicity to the animal cell, thus causing no death of the animal cell.

Antiviral agent against animal viruses

There are provided a Kringle domain structure, comprising: inducing artificial mutations at amino acid residues except for conserved amino acid residues that are important to maintain the structural scaffold of a Kringle domain; and protein scaffold variants, based on the Kringle domain structure, which modulate the biological activities of a variety of target molecules derived from the protein scaffold library by specifically binding to the target molecules. Also, there is provided a method for constructing homo-/hetero-oligomers which allow multi-specificity binding to multiple targets by the tandem assembly monomeric Kringle domain variants using a linker. Additionally, there is provided a method for preparing multispecific monomers and multivalent monomers by grafting target-binding loops of a Kringle domain variant into non-binding loops of another Kringle domain variant with the same or different target binding specificity. Furthermore, a protein scaffold variant based on the Kringle domain structure that specifically binds to target molecules, DNA encoding the protein scaffold variant, or a method and composition for prevention, detection, diagnosis, treatment or relieving diseases or disorders, particularly cancers and other immune-related diseases, comprising: administering an effective amount of the related molecule to animals, preferably human.

Protein scaffold library based on kringle domain structure and uses thereof

Growing community of inventors

Gyeonggi-do, South Korea

Myung-Hee Kwon