Korea Research Institute of Bioscience and Biotechnology

Snu Rdb Foundation

Medicinal Bioconvergence Research Center

Myung Hee Kim

Jung Won Hwang

Chul Ho Lee

Sung Hoon Kim

Sang Ho Choi

Eun Young Lee

Tae Kwang Oh

Byoung Sik Kim

The present invention relates to an EPRS (glutamyl-prolyl-tRNA synthetase) protein or a fragment thereof. The EPRS protein of the present invention or fragment thereof may bind to PCBP2 protein to activate the MAVS signaling pathway, and thus it has anti-RNA viral effects, thereby being effective for preventing or treating a RNA viral infectious disease.

Anti-RNA virus composition comprising EPRS protein or fragment thereof

The present invention relates to a modified TXNIP protein, a method for preparing the modified TXNIP protein, a polynucleotide encoding the modified protein, an expression vector including the polynucleotide, a transformant introduced with the expression vector, a method for crystallizing a modified TRX-TXNIP complex using the modified TXNIP protein, and a method for screening a substance regulating interaction between TRX and TXNIP, an inhibitor of TRX activity, or a substance regulating TXNIP function.

Method for crystallization of TRX-TXNIP complex mutein and 3D structure thereof

The present invention relates to a three-dimensional structure of a complex explored by crystallization of the complex of NanR which is a key pathogenic regulatory protein ofand ManNA6P which is a NanR regulator. Further, the present invention relates to a modified NanR protein, a polynucleotide encoding the protein, a vector including the polynucleotide, and a transformant including the vector. Furthermore, the present invention relates to a method for screening a substance regulating interaction between NanR and the transcriptional control region of nan operon which is a gene cluster regulated by NanR, or a substance regulating interaction between NanR and ManNAc-6P, by designing three-dimensional structure of the complex, and to an antibacterial composition including the screened substance.

Crystal structure of the NanR and ManNAc-6P complex, and uses thereof

Growing community of inventors

Daejeon, South Korea

Myung Hee Kim