Korea Research Institute of Chemical Technology

Korea Research Institute of Bioscience and Biotechnology

Myung Ae Bae

Ki Young Kim

Jung Nyoung Heo

Sung Hoon Ahn

Seong Hwan Kim

Byoung-Mog Kwon

Nam Sook Kang

Sang Dal Rhee

Dong Cho Han

Won Hoon Jung

Hyae Gyeong Cheon

Sung Youn Chang

Sung-eun Yoo

Dong Ju Jeon

Yong Ki Min

Byoung Mog Kwon

Nack Jeong Kim

Eun Sook Hwang

Jin Hee Ahn

Seung Kyu Kang

Jong Hwan Song

Sung Eun Yoo

Young Sik Cho

Jin Sook Song

Gehyeong Lee

Zaesung No

Chang Min Park

Hee Youn Kim

Ikyon Kim

Provided is a sulfamide derivative having an adamantyl group represented by the following Formula 1, or a pharmaceutically acceptable salt thereof. The sulfamide derivative suppresses the activity of 11&#x3b2;-hydroxysteroid dehydrogenase type 1 (11&#x3b2;-HSD1), and is useful in the treatment of various diseases that are mediated by 11&#x3b2;-HSD1. 

Sulfamide derivative having an adamantyl group and its pharmaceutically acceptable salt

An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.

Indenone derivative and pharmaceutical composition comprising same

The present invention relates to a pharmaceutical composition for the prevention or treatment of bone diseases comprising colforsin daropate, and more particularly, the present invention relates to a pharmaceutical composition for the prevention or treatment of bone diseases such as bone fracture and osteoporosis, which inhibits osteoclast differentiation and bone resorption caused by osteoclasts and promotes osteoblast differentiation and the activity of osteoblasts, and a health functional food composition comprising colforsin daropate.

Method for the treatment of bone diseases comprising colforsin daropate

The present invention relates to novel {7-(3',4&#x2032;-dialkoxyphenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine compounds or pharmaceutically acceptable salts thereof, a process for preparing the same, and pharmaceutical compositions for treating or preventing inflammatory diseases including asthma and chronic obstructive pulmonary disease, arthritis, atopic dermatitis, cancers including leukemia, and degenerative brain diseases including Alzheimer's disease, depression and memory impairment, which comprises the same as an active ingredient.

7-(3',4&#x2032;-Dialkoxyphenyl)[1,2,4]-triazolo[1,5-A]pyrimidine compounds, process for preparing thereof, and pharmaceutical composition for treating or preventing asthma, chronic obstructive pulmonary disease, arthritis, atopic dermatitis, tumor and degenerative brain diseases comprising the same

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Daejeon, South Korea

Myung Ae Bae