Miles Laboratories, Inc.

Myron C Rapkin

David L Tabb

Robert Bauer

Charles Tak Lam

Louis G Daunora

Carmine M Greene

Leonard P Fenocketti

Nancy K Barton

Loren John Van Der Werf

A urobilinogen control standard composition, control standard device and a method for preparing such composition are disclosed. The composition comprises a substituted indole:nonionic detergent solution which is reactive with p-diethylaminobenzaldehyde and hydrochloric acid. The composition is produced by dissolving the substituted indole in a selected nonionic detergent and diluting the solution to a predetermined level. The device is a carrier matrix impregnated with a solution of a substituted indole and a nonionic detergent.

Method and composition for urobilinogen control standard

A method and test device for determining the glucose concentration in a test sample containing from 1/2 to 5 percent glucose. The method and test device involve incorporating urea-formaldehyde resin in a carrier matrix and subsequently impregnating the carrier with an enzymatic testing composition which includes glucose oxidase, a peroxidatively-active compound and a chromogen. Contact of the carrier with a glucose-containing test sample produces a detectable response whereby the glucose concentration can be determined.

Method and device for detecting glucose concentration

A test device for detecting the presence of constituents in a liquid test sample, and method for preparing it are disclosed. The device comprises a base support member coated with a hydrophobic barrier layer onto which is affixed a plurality of spaced apart reagents respectively responsive to different constituents of the test sample. The barrier layer comprises finely divided silica particles, to the surface of which are randomly covalently bound groups having the structure

Test device resistant to cross contamination between reactant areas and

A device and method are disclosed for preparing a bilirubin-containing control solution. The device comprises a carrier vehicle having incorporated with it unconjugated bilirubin and certain dyes. Upon contact with a predetermined quantity of water a control solution results, which will simulate a pathological specimen of conjugated bilirubin-containing solution, upon analysis.

Device and method for simulating bilirubin in urine

A device and method for preparing a ketone body control solution. The device comprises a carrier vehicle having incorporated with it a metal ion complex of a dione compound. The dione compound is characterized as having the structure ##STR1## wherein R and R', same or different, are alkyl groups having 1 to about 6 carbon atoms. The method for preparing the control solution comprises contacting a predetermined volume of liquid with the device.

Device and method for preparation of a control solution for ketone

A test device for determining the presence of a liquid sample constituent. The device comprises a base support member having attached to it an indicator member which produces a detectable response, such as a color change, in the presence of the sample constituent. The indicator member comprises an upper reagent layer, a lower absorbent layer and a substantially sample-impervious barrier layer between the upper and lower layers. The indicator member is attached to the base member along the lower side of the absorbent layer.

Multilayered test device for determining the presence of a liquid sample

A method for determining the freeze point of an antifreeze-containing solution which includes simply dipping into the solution to be tested a bibulous material incorporated with a pH indicator and a buffer for maintaining the pH of the absorbed solution near or within the color change range of the indicator and comparing any apparent color change developed thereon to a color chart correlated to indicate various colors corresponding to various freeze points of antifreeze-containing solutions.

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Elkhart, IN, United States of America

Myron C Rapkin