Centre National De La Recherche Scientifique

Sanofi

Myriem Skander

Patrick Mailliet

Angela Marinetti

The invention relates to the platinum N-heterocycle derivatives of general formula (I) in which&#x2014;Rand/or Rare, independently of one another, an aryl or aralkyl group, each optionally substituted, a linear or branched C1-C6 alkyl group, a monocyclic C3-C7 cycloalkyl group or a linear or branched C2-C6 alkenyl group, or else R' is a hydrogen atom and R is a group selected from the following groups: cycloalkyl or heterocycloalkyl, which is monocyclic or bicyclic and has from 3 to 8 carbon atoms, or benzyl, which is optionally substituted, or else R and R&#x2032; form, together with NH, a C3-C8 monocyclic or bicyclic heterocycloalkyl, V is a nitrogen atom or a C&#x2014;Rradical, Rand/or Rare hydrogen or a phenyl group or Rand Rmay also together form a C3-C6 alkylene radical or a C3-C6 heteroalkylene radical with one or more nitrogenous heteroatoms, it being possible for the carbon atoms of the heteroalkylene radical to be modified in the form of a carbonyl radical, and X is iodine, bromine, chlorine or a nitrato (&#x2014;ONO) group.

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Gif sur Yvette, France

Myriem Skander