Oncomatryx Biopharma, S.l.

Advanced in Vitro Cell Technologies, S.l.

Advancell Advanced in Vitro Cell Technologies, S.a.

Myriam Fabre

Roland Kontermann

Klaus Pfizenmaier

Laureano Simon

Cristina Ferrer

Sonia Gonzalez Menoyo

Mariana Lopez Matas

Roser Pagan I Esquius

The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula I:A-(L-D)p&#x2003;&#x2003;(I)or a pharmaceutically acceptable salts or solvates thereof,wherein:A is an antibody that selectively binds FAP;L is a linker;D is a drug comprising a cytolysin or a Nigrin-b A-chain; andp is 1 to 10, and to use of such conjugates in the therapeutic treatment of tumors. Methods of producing such conjugates and components for use in such methods are disclosed.

Antibody-drug conjugates and immunotoxins

The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula I: A-(L-D)p (I) or a pharmaceutically acceptable salts or solvates thereof, wherein: A is an antibody that selectively binds FAP; L is a linker; D is a drug comprising a cytolysin or a Nigrin-b A-chain; and p is 1 to 10, and to use of such conjugates in the therapeutic treatment of tumors. Methods of producing such conjugates and components for use in such methods are disclosed.

The present invention relates to conjugates, in particular antibody-drug conjugates and immunotoxins, having the formula I: A-(L-D)p (I) or a pharmaceutically acceptable salts or solvates thereof, wherein: A is an antibody that selectively binds Endoglin; L is a linker; D is a drug comprising a cytolysin or a Nigrin-b A-chain; and p is 1 to 10, and to use of such conjugates in the therapeutic treatment of tumors. Methods of producing such conjugates and components for use in such methods are disclosed.

The invention relates to a method of storing and/or transporting in vitro two-dimensional cell cultures. The inventive method comprises the following steps consisting in: a) coating a cell culture that is immobilized on an asymmetric support with a gelatine solution in culture medium at a concentration of between 1 and 5%; b) solidifying the gelatine added to the support at a temperature of between 15 and 25&#xb0; C.; and c) storing and/or transporting the cell culture at a temperature of between 15 and 25&#xb0; C. for a period of up to 96 hours. The invention also relates to a kit which is used to store and/or transport the in vitro two-dimensional cell cultures according to the inventive method, said kit comprising: i) an asymmetric support, and (ii) a gelatine solution in culture medium at a concentration of between 1 and 5%.

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Barcelona, Spain

Myriam Fabre