Biopolymer Engineering, Inc.

The Collaborative Group, Ltd.

Biopolymer Engineering Pharmaceutical, Inc.

Myra L Patchen

Gary R Ostroff

Spiros Jamas

D Davidson Easson, Jr

Paul Bleicher

The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble &#x3b2;-glucan composition comprising &#x3b2;-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).

Very high molecular weight &#x3b2;-glucans

The invention pertains to compositions and therapeutic and prophylatic methods for treating/preventing infections in an animal or human by administering a soluble &bgr;-glucan composition comprising &bgr;-glucan molecules having an average molecular weight of at least 1,000,000 daltons, as determined by multi-angle laser light scattering (VHMW-glucan).

Very high molecular weight &bgr;-glucans

Methods for inducing mobilization of peripheral blood precursor cells, for elevating levels of peripheral blood precursor cells and facilitating hematopoietic reconstitution in a mammal are disclosed, comprising administering to the mammal an effective amount of an underivatized, aqueous soluble .beta.(1,3)-glucan in a triple helix conformation, which does not stimulate or prime the production of proinflammatory cytokines in vitro.

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Framingham, MA, United States of America

Myra L Patchen