Samsung Electronics Co., Ltd.

Myo-yong Lee

Ye-ryoung Yong

Kyung-hee Park

Hyun-ju Kang

Dong-hyun Park

Ga-hee Kim

Kak Namkoong

Joon-Ho Kim

Chang-eun Yoo

Won-seok Chung

Nam Huh

Young-a Kim

Woochang Lee

Yeon-ja Cho

Sung-woo Hong

Young-nam Kwon

Shin-i Yoo

Jeong-gun Lee

Jeo-young Shim

Kwang-ho Cheong

Jong-suk Chung

Ki-woong Han

Kyu-Sang Lee

Seung-yeon Yang

Joong-gun Lee

Provided are compositions, kits, and methods for detecting a vesicle comprising a membrane permeable marker that is converted into a detectable marker inside the vesicle.

Compositions and kits comprising a membrane permeable marker that is converted into a detectable marker inside a microvesicle, and methods for detecting and analyzing microvesicle

Provided is a method of monitoring a vesicle in a sample, including contacting a vesicle in a sample with a membrane permeable marker that is converted into a detectable marker in the vesicle, measuring a signal of the detectable marker, and monitoring the vesicle based on the measured signal.

Method for monitoring vesicles using a membrane-permeable marker that is converted into a membrane-nonpermeable marker

A breast cancer diagnostic composition and kit, and methods of diagnosing breast cancer or acquiring information for breast cancer diagnosis by using the composition or kit are provided. The composition or kit includes a polynucleotide that is the same as or complementary to at least one microRNA (miRNA) selected from the group consisting of hsa-miR-126, hsa-miR-23a, hsa-miR-24, hsa-miR-19b, hsa-miR-103, hsa-miR-142-3p, hsa-miR-144, hsa-miR-15a, hsa-miR-185, hsa-miR-93, and hsa-miR-30c in a vesicle, or a fragment of the microRNA.

Composition and kit for diagnosing breast cancer including polynucleotide within vesicle, and method of diagnosing breast cancer using the same

Provided is a dual-hybridization polynucleotide including a first complementary region that is complementary to the 3'-terminus of a target nucleic and a second complementary region that is complementary to the 5&#x2032;-terminus of the target nucleic acid, a composition and kit including the polynucleotide, and a method of producing a nucleotide sequence complementary to the target nucleic acid. The first complementary region to be bound at the 3&#x2032;-terminus of the target nucleic acid can be shortened and the target nucleic acid may be amplified with excellent specificity and/or sensitivity.

Polynucleotide and use thereof

A composition, a kit, and a method of isolating a vesicle from a sample using a compound comprising zwitterion moieties, which may be used to analyze vesicles, and proteins, glycoprotein, lipids, or nucleic acids thereof.

Compositions, kits, and methods for isolating vesicles

A first polynucleotide including at least two complementary regions that are complementary to a target nucleic acid and have a reverse configuration, a second polynucleotide complementary to the first polynucleotide, and uses thereof, are provided.

A microarray package device and a method of manufacturing the same. An effective microarray analyzing reaction is performed by using the microarray package device that provides structural stability and reliable experimental results.

Microarray package device and method of manufacturing the same

A microarray reaction device includes a fluid container, a reaction chamber, a first channel connected with the fluid container, a second channel connected with the reaction chamber, and a valve. The valve includes a first and second support unit, respectively including a first and second penetration opening unit, extended through a first and second surface thereof. The first and second penetration opening unit is connected to a second end of the first and second channel, respectively. The second support unit includes a third penetration opening unit extended through a second surface thereof. The first and second surfaces contact each other, such that the first support unit and the second support unit are slidably disposed with each other. The microarray reaction device further includes a storing chamber connected with the third penetration opening unit, and a pump connected to the storing chamber and providing pressure to the storing chamber.

Microarray reaction device and method of using the same

Provided are a method of analyzing a sequence of a first probe nucleic acid using a substrate on which a second probe nucleic acid is immobilized, and a microarray and a kit for the same.

Method of analyzing probe nucleic acid, microarray and kit for the same

Disclosed is a method of separating small RNAs of 200 nucleotides or less from larger RNAs on a solid support, using a kosmotropic salt of different concentrations.

Method of separating small RNA molecules using kosmotropic salt

The present invention provides a method of purifying RNA, including contacting a solid support with an acidic solution having a RNA-containing sample and a kosmotropic salt having a concentration of less than 1M, thereby binding the RNA to the solid support. According to the present invention, RNA is purified efficiently due to high RNA yield and low contamination by DNA. The present invention is particularly effective in purifying RNAs of 200 nucleotides or less.

Method of purifying RNA using kosmotropic salt

A method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser are provided. According to the method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser, cell lysis within 40 seconds is possible, the apparatus can be miniaturized using a laser diode, a DNA purification step can be directly performed after a disruption of cells or viruses, and a solution containing DNA can be transferred to a subsequent step after cell debris and beads to which inhibitors of a subsequent reaction are attached are removed with an electromagnet. In addition, by means of the cell lysis chip, an evaporation problem is solved, vibrations can be efficiently transferred to cells through magnetic beads, a microfluidics problem on a rough surface is solved by hydrophobically treating the inner surface of the chip, and the cell lysis chip can be applied to LOC.

Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser

Provided are methods of isolating and amplifying nucleic acids from and in a nucleic acid-containing sample. The nucleic acid isolation method includes contacting a nucleic acid-containing sample to a silanized solid support to capture nucleic acids to the silanized solid support and treating the nucleic acid-captured solid support with an alkaline solution of pH 9 to 14. The nucleic acid amplification method includes contacting a nucleic acid-containing sample to a silanized solid support to capture nucleic acids to the silanized solid support; treating the nucleic acid-captured solid support with an alkaline solution of pH 9 to 14; and adding a nucleic acid amplification solution to the resultant solution after the alkaline solution treatment to perform nucleic acid amplification.

Methods of isolating and amplifying nucleic acids using silanized solid support

A method of removing air bubbles from a hybridization solution in a microarray-coverslip assembly c including injecting a solution of magnetic particles between the coverslip and microarray, applying a magnetic field to the microarray-coverslip assembly, moving the magnetic particles and removing air bubbles in the hybridization solution from a hybridization area of the microarray with the magnetic particles, and a microarray kit for the same.

Growing community of inventors

Suwon-si, South Korea

Myo-yong Lee