Biomerieux, Inc.

Biomerieux Sa

Mylene Lesenechal

Glaucia Paranhos-Baccala

Michel C Jolivet

Bernard F Mandrand

Colette Jolivet-Reynaud

Nicole Battail-Poirot

Laurence Becquart

The present invention relates to a monoclonal antibody capable of binding to a wild-type HBsAg antigen and to at least one, preferably at least two and advantageously more than two, mutant forms of the HBsAg antigen, said monoclonal antibody binding to a peptide sequence consisting of at least 6 contiguous amino acids in the 199-208 region of the HBsAg antigen, and advantageously binding to the peptide sequence constituted by the 199-208 region of the HBsAg antigen.

Monoclonal antibodies directed against hepatitis B viruses

The nucleotide sequence of Tc100, a gene encoding PTc100, a new Trypanosoma antigen, and the amino acid sequence of PTc100 are described. Tc100 and PTc100, or fragments thereof, modified or otherwise, can be used directly or indirectly for the detection of, or for the monitoring of the infection generated by, in man or in animals.

Trypanosoma cruzi antigen, gene encoding therefor and methods of detecting and treating chagas disease

The nucleotide sequence of Tc100, a gene encoding a new antigenic protein from called PTc100, is disclosed. The amino acid sequence of the PTc100 protein is also disclosed, along with the amino acid sequence of the dominant antigenic epitope of the PTc100 protein. The PTc100 protein and Tc100 gene, or a fragment thereof, modified or otherwise, can be used directly or indirectly for the detection of or for the monitoring of an infection generated by in man or animals.

Trypanosoma cruzi antigen, gene encoding therefore, and methods of detecting and treating chagas disease

The nucleotide sequence of Tc100, a gene encoding PTc100, a new Trypanosoma antigen, and the amino acid sequence of PTc100 are described. Tc100 and PTc100, or fragments thereof, modified or otherwise, can be used directly or indirectly for the detection of,, or for the monitoring of the infection generated by,, in man or in animals.

The present invention relates to a new Trypanosoma cruzi antigen, called PTc100, and to a code gene �sic! encoding the latter, called Tc100. According to the invention, the nucleotide sequences of Tc100 and the amino acid sequences of PTc100 were determined and described. PTc100 and Tc100, or fragments thereof, modified or otherwise, can be used directly or indirectly for the detection of Trypanosoma cruzi, or for the monitoring of the infection generated by the latter, in man or in animals.

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Villeurbanne, France

Mylene Lesenechal