Japan Tobacco Inc.

Yoshitomi Pharmaceutical Industries, Ltd.

Mutsuyoshi Matsushita

Junichi Haruta

Hiromasa Hashimoto

Itsuo Uchida

Akira Saito

Hiromitsu Watanabe

Noboru Furukawa

Katsuyoshi Hara

Koretake Anami

Kunio Iwata

Yoshifumi Ueda

Akihiro Yasuda

Sotaro Takigawa

Hiroaki Hari

Naoki Miyagawa

Yuji Hamada

Yoshihiro Kitagawa

Tetsuya Hondo

Akira Matsuo

Tatsuya Maekawa

Provided is a therapeutic or prophylactic agent for pain or interstitial cystitis comprising N-[2-(6,6-dimethyl-4,5,6,7-tetrahydro-H-indazol-3-yl)-1H-indol-6-yl]-N-methyl-(2S)-2-(morpholin-4-yl)propanamide or a pharmaceutically acceptable salt thereof.

Method of treating pain or interstitial cystitis using indole compound

Heterocyclic aromatic oxazole compounds and use thereof

Oxazole derivatives of the formula (I) ##STR1## wherein one of R and R.sub.1 is a methylsulfonylphenyl, an aminosulfonylphenyl or an alkylaminosulfonylphenyl, and the other is a cycloalkyl having 5 to 7 carbon atoms which is optionally substituted by lower alkyl, a thienyl optionally substituted by lower alkyl or halogen atom or a furanyl optionally substituted by lower alkyl or halogen atom, and R.sub.2 is a lower alkyl, and pharmaceutically acceptable salts thereof. The oxazole derivatives and pharmaceutically acceptable salts thereof have superior antipyretic action, analgesic action, anti-inflammatory action, and particularly, selective inhibitory action on cyclooxygenase-2 (COX-2), and are expected to be useful as an antipyretic agent, an analgesic agent and an anti-inflammatory agent with less side-effects such as disorders in the digestive tract.

Oxazole derivatives and use thereof

Novel peptide derivatives of the following formula ##STR1## wherein each symbol is as defined in the specification, pharmaceutically acceptable acid addition salts thereof and analogous copounds thereof. Since the derivatives and their pharmaceutically acceptable acid addition salts of the present invention possess stronger actions on central nervous system (e.g. antagonistic action against hypothermia, locomotor stimulant action, signal reflex stimulant action), they are of use as a therapeutic medicament for central nervous disorders such as impaired consciousness, depression, hypomnesia, the like in association association with schizophrenia, melancholia, senile dementia, sequelae of cerebrovascular disorders, head trauma, epilepsy and spinocerebellar degeneracy.

Histidyl peptide derivatives

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Takatsuki, Japan

Mutsuyoshi Matsushita