Sekisui Kagaku Kogyo Kabushiki Kaisha

Sekisui Chemical Co., Ltd.

Mutsumi Fukuda

Seiichirou Honda

Hiroshi Ogawara

Taro Suzuki

Masato Azuma

Takashi Nakagawa

Takaji Kishi

Hiroko Tsukahara

Michiharu Ando

Hiroshi Kuroda

Masahachi Yoshioka

Kunio Yoneto

The present invention provides a pharmaceutical preparation for percutaneous absorption comprising a drug-impermeable substrate having provided thereon an adhesive layer comprising a drug and a drug dissolution aid, characterized in that said adhesive is composed of a copolymer essentially consisting of 5 to 35 wt % of N-vinyl-2-pyrrolidone and 65 to 95 wt % of an acrylic acid ester, 3 to 30 wt % of a homopolymer of N-vinyl-2-pyrrolidone is contained in said adhesive layer as the drug dissolution aid, and said drug is a hydrophilic drug having a saturation solubility of 6 to 50 wt % to N-vinyl-2-pyrrolidone. Where the hydrophilic drug is Piroxicam, it is preferred to use a polyoxyethylene alkyl ether and/or a fatty acid alkylolamide as an absorption enhancer in combination.

Pharmaceutical preparation for percutaneous absorption

A percutaneous pharmaceutical preparation in tape form is provided. The preparation comprises a flexible backing, which is not permeable to an active ingredient, and an adhesive layer formed on the flexible backing, the adhesive layer comprising an adhesive base material and an active ingredient compatible with the adhesive base material, wherein the adhesive base material consists essentially of a copolymer containing 2-ethylhexyl acrylate in a concentration of 45 to 80 mol % and N-vinyl-2-pyrrolidone in a concentration of 20 to 55 mol %, and the active ingredient is estradiol and/or the esters thereof which are contained in a concentration of 6 to 25% by weight of the total amount of the adhesive base material and the active ingredient.

Percutaneous pharmaceutical preparation

A percutaneous administration type pharmaceutical preparation in tape form comprising a flexible backing, which is not permeable by the active ingredient, and an adhesive base layer formed on said flexible backing; said adhesive base layer consisting essentially of an adhesive base material and an active ingredient compatible with said adhesive base material, wherein said adhesive base material is a copolymer containing 2-ethylhexyl acrylate (EHA) in a concentration of 45 mole% or more and N-vinyl-2-pyrrolidone (VP) in a concentration of 20 to 55 mole%, and said active ingredient is isosorbide dinitrate (ISDN) which is contained in a concentration of 10% by weight or more in said adhesive base material.

A blood-partitioning composition comprising a mixture of

Composition for partitioning blood components

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Osaka, Japan

Mutsumi Fukuda