Eisai Company, Limited

Mutsuko Tabata

Yoshinori Takahashi

Shigeki Hibi

Hisashi Shibata

Kouichi Kikuchi

Motohiro Soejima

Yorihisa Hoshino

Kogyoku Shin

Tatsuya Yoshiuchi

Tetsuya Hirakawa

Toshihiko Kaneko

Fumihiro Ozaki

Masayuki Matsukura

Kazuki Miyazaki

Takayuki Hida

Ichiro Yoshida

Hiroki Ishihara

Kohei Sawada

Junichi Kamata

Mitsuhiro Ino

Hiroshi Katoh

Takashi Yoshinaga

Kiyoaki Kobayashi

Tatsuhiro Onogi

Hiroyuki Suzuki

Miyuki Ohkubo

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof,wherein Ris a hydrogen atom, etc.; Ris a hydrogen atom, etc.; M' represents a hydrogen atom, a halogen atom or a Calkyl group; R&#x2032; represents a hydrogen atom or a Calkyl group; and W&#x2032; represents a phenyl group, pyridyl group, thienyl group, or furyl group, each being optionally substituted; and a pharmacologically acceptable salt thereof or hydrates thereof.

Tricyclic fused heterocyclic compound, process for preparing it and medicament comprising it

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof.Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula &#x2014;(CRR)&#x2014; (wherein Rand Rare the same as or different from each other and each represents a Calkyl group etc.), &#x2014;NR&#x2014; (wherein Rrepresetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula &#x2014;(CRR)&#x2014; (wherein Rand Rare the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with Calkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted Calkyl group etc.; and the partial structuremeans a single or double bond.

Fused heterotricyclic compounds, process for preparing the compounds and drugs containing the same

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof,wherein

Piperidine compound and pharmaceutical composition thereof

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Ibaraki, Japan

Mutsuko Tabata