Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Mutsuko Ono

Shigeki Hibi

Yoshinori Takahashi

Hisashi Shibata

Motohiro Soejima

Yorihisa Hoshino

Koichi Kikuchi

Kogyoku Shin

Tatsuya Yoshiuchi

Mitsuhiro Ino

Tetsuya Hirakawa

Koki Kawano

Fumihiro Ozaki

Yoshihiko Norimine

Kohei Sawada

Takashi Yoshinaga

Kiyoaki Kobayashi

Hiroe Minami

Hiroyuki Suzuki

Tatsuhiro Onogi

Compounds represented by the following general formula: [wherein X, X, Xand Xeach independently represent a single bond, Calkylene, etc.; Arepresents optionally substituted phenyl, etc.; Arepresents an optionally substituted 5- to 7-membered heterocyclic group containing &#x2014;C(=Q)- (wherein Qrepresents oxygen, sulfur or &#x2550;N&#x2014;R(wherein Rrepresents hydrogen or Calkyl)) and nitrogen, etc.; and Zrepresents piperidin-diyl, etc.],salts thereof and hydrates of the foregoing.

Nitrogen containing heterocyclic compounds and medicines containing the same

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein Rdenotes a hydrogen atom, a Calkyl group, a Calkoxy group and the like; Rdenotes a halogen atom, a cyano group, a nitro group, a Calkyl group, a Calkenyl group, Calkynyl group and the like; Rdenotes a Caromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR(wherein Rdenotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated Calkyl group and the like) and, in this case, at least two of X, Y and Z denote CR.

Imidazo[1,2-b]pyridazine compound

Compounds represented by the general formula: [wherein Rrepresents methoxy, ethyl, methylthio, etc., R, Rand Reach represent hydrogen, a halogen, etc., Rand Reach represent &#x2014;X&#x2014;X&#x2014;X(wherein Xrepresents a single bond or &#x2014;CO&#x2014;, Xrepresents a single bond, &#x2014;NR, etc. and Xand Reach represent hydrogen, Calkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.

Pyrazolo[1,5-a]pyridines and medicines containing the same

Pyrazolo[1,5-a] pyridines and medicines containing the same

The present invention provides compounds represented by the following formula:wherein X, X, Xand Xeach independently represents a single bond, Calkylene, etc.; Arepresents optionally substituted phenyl, etc.; Arepresents an optionally substituted 5- to 7-membered heterocyclic group containing &#x2014;C(&#x2550;Q)&#x2014;, Qwherein represents oxygen, sulfur or &#x2550;N&#x2014;R, wherein Rrepresents hydrogen or Calkyl etc.; and Zrepresents piperidin-diyl, ect, salts thereof and hydrates of the foregoing.

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Ushiku, Japan

Mutsuko Ono