University of California

Augusta University Research Institute, Inc.

Medical College of Georgia Research Institute, Inc.

Georgia Health Sciences University Research Institute, Inc.

Muthusamy Thangaraju

Vadivel Ganapathy

Puttur D Prasad

Thomas Weimbs

Jacob Torres

Gail Cresci

Compositions and methods for supporting health, especially renal health, comprising ketonic agents that recapitulate beneficial effects of ketosis by exogenously administered agents. The agents include BHB, analogs thereof, and GPR109A agonists. The agents may further include crystal precipitation inhibitors which synergistically improve treatment of certain renal conditions. The agents may be used in dietary supplements and therapeutic compositions for the treatment of cystic kidney diseases such as polycystic kidney disease, ciliopathies, and other conditions.

Methods and compositions for supporting renal health

The present invention includes inhibitors of the amino acid transporter ATBand methods of uses thereof.

Inhibitors of the ATB(0,+) transporter and uses thereof

Pharmaceutical compositions containing an effective amount of a ligand for GPR109 to decrease intracellular cAMP levels of a subject in combination with an effective amount of a DNA methyl transferase inhibito to reduce or inhibit downregulation of GPR109 in the intestinal epithelial cells of the subject relative to a control are provided. It has been discovered that ligands for GPR109 can be used to treat one or more symptoms of cancer, inflammatory disorders, and diarrhea. Representative CPR109 ligands include, but are not limited to butyrate, &#x3b2;-hydroxybutyrate, nicotinic acid, acifran, and octanoate. Suitable DNA methyl transferase inhibitors include 5-azacytidine, 5-aza-2'-deoxytidine, 1-&#x3b2;-D-arabinfarnosyl-5-azacytosine and dihydro-5-azacytidine. Typically, the compositions are formulated to achieve a GPR109 ligand serum blood level of about 1 to about 1000 &#x3bc;M. The compositions are useful for the treatment of one or more symptoms of cancer. Preferred cancers that can be treated using the disclosed compositions include, but are not limited to colon cancer, breast cancer and leukemia. Methods for treating cancer, inflammatory disorders, and diarrhea are also provided.

Compositions comprising a GPR109 ligand for treating disorders of the digestive tract and/or cancer

Growing community of inventors

Evans, GA, United States of America

Muthusamy Thangaraju