Sun Pharmaceutical Industries Limited

Sun Pharma Advanced Research Company Limited

Muthukumaran Natarajan

Rajamannar Thennati

Nishith C Chaturvedi

Dhiren Rameshchandra Joshi

Rishit Mansukhlal Zalawadia

Abhishek Tiwari

Brijeshkumar Patel

Ravishankara Madavati Nagaraja

Krunal Harishbhai Soni

Vinod Sampatrao Burade

Vipulkumar Shankarbhai Patel

Pradeep Dinesh Shahi

Kunal Pandya

Nileshkumar Sureshbhai Patel

Srinivasu Kilaru

Mandakini Muthukumaran

Mehul Chandrakatbhai Bhatt

The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.

GLP-1 analogues

A process for preparing 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide, compound of formula (I), said process comprising a. reacting compound of formula (Ivb) with alkali metal methoxide to yield compound of formula (II); and b. converting compound of formula (II) to compound of formula (I). 

Process for the preparation of 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide

Stable polymorphic forms III, IV and substantially amorphous form of an anticonvulsant, tiagabine hydrochloride.

Stable polymorphic forms of an anticonvulsant

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Gujarat, India

Muthukumaran Natarajan