Council of Scientific and Industrial Research

Muthukrishnan Murugan

Mukund Keshav Gurjar

Ramesh Anna Joshi

Sanjay Pandurang Borikar

Mujahid Mohammad

Dinesh Ramesh Garud

Mohammad Mujahid

Prashant Pramod Mujumdar

Dinesh Rämesh Garud

Prashant Pramod Majumdar

The present disclosure provides a process for synthesis of 3-aryl-2-hydroxy propanoic acid derivatives of formula (S)-1. wherein Rrepresents H or (C-C) alkyl groups and Rrepresents (C-C) alkyl groups. 

Process for the preparation of 3-aryl-2-hydroxy propanoic acid compounds

An efficient synthesis of the anticonvulsant drug, Pregabalin hydrochloride is described using simple transformations in high enantiopurity (&#x3e;99% ee) and overall yield of 44 to 50%.

Process for the preparation of an anticonvulsant agent pregabalin hydrochloride

Disclosed herein a novel, process for the preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline [(S)-1]. Particularly, the invention relates to the synthesis of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline with excellent selectivity starting from commercially available enantiopure (R)-epichlorohydrin [(R)-2] via formation of aziridine intermediate [(S)-4].

Process for the preparation of (S)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methyl aniline

The present invention relates to the improved and efficient process for the synthesis of antiepileptic drug Lacosamide in high enantiopurity (&#x3e;98% ee) and better yield. More particularly, the present invention relates to improved and efficient, cost effective process for synthesis of desired (R) isomer of Lacosamide starting from commercially available (S)-benzyl glycidyl ether.

Process for the synthesis of antiepileptic drug lacosamide

The present invention relates to RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol of the formula (1), process for preparation thereof by selective allylation of p-hydroxy phenyl ethanol and use thereof in a preparation of RS betaxolol of formula (2) 

RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol, process for preparation thereof and process for preparation of RS betaxolol

The present invention relates to an improved process for preparation of S-(&#x2212;)-betaxolol salts. More particularly the present invention relates to the preparation of hydrochloride salt of S-(&#x2212;)-betaxolol of formula (1)

Process for preparation of S-(-)-betaxolol and salts thereof

The present invention relates to a novel compound S-(&#x2212;)-1-{4-[2-(allyloxy)-ethyl] phenoxy}-3-isopropylamino propan-2-ol of formula 1 and to a process for the preparation thereof. More particularly the present invention relates to a process for preparing S-(&#x2212;)-1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol of formula 1 by selective allylation of p-hydroxy phenyl ethanol. The present invention also relates to a process for conversion thereof to S-(&#x2212;)-betaxolol of formula 2

S-(&#x2212;)-1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol, process for preparation thereof and process for preparation of S-(&#x2212;)betaxolo

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Pune, India

Muthukrishnan Murugan