Bristol-Myers Squibb Compnay

Murugaiah Andappan Murugaiah Subbaiah

John E Macor

Sing-Yuen Sit

William John Pitts

Guanglin Luo

Scott Hunter Watterson

Jie Chen

Carolyn Diane Dzierba

Junqing Guo

Jianliang Shi

Steven H Spergel

Michael E Mertzman

Saleem Ahmad

James Aaron Balog

Yong-Jin Wu

David S Weinstein

Amy C Hart

William N Washburn

Steven P Seitz

David K Williams

Brian Lee Venables

Ryan M Moslin

Hua Gong

Zhizhen Barbara Zheng

Jason M Guernon

Carolyn A Weigelt

Compounds having formula (I)-(IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Aminotriazolopyridines as kinase inhibitors

The disclosure relates to compounds of formula I which are useful as kinase modulators including RIPK 1 modulation. The disclosure also provides methods of making and using the compounds for example in treatments related to necrosis or inflammation as well as other indications. 

Aminopyrrolotriazines as kinase inhibitors

The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed. 

Inhibitors of indoleamine 2,3-dioxygenase and methods of their use

Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX). 

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are melanin concentrating hormone receptor-1 (MCHR1) antagonists which may be used as medicaments. 

Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists

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Tamil Radu, India

Murugaiah Andappan Murugaiah Subbaiah