Transtech Pharma, Inc.

Murty N Arimilli

Adnan M M Mjalli

Robert Carl Andrews

Jeff Jiqun Zhu

Govindan Subramanian

Stephen Thomas Davis

Ramesh Gopalaswamy

Guoxiang Huang

Muralidhar Bondlela

Brian S Grella

Xiaochuan Guo

Mustafa Guzel

Bapu Reddy Gaddam

Samuel F Victory

Thomas Scott Yokum

Mohan Rao

Ghassan Qabaja

Xiao-Chuan Guo

Ye Edward Tian

John Dankwardt

The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.

Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors

The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.

Substituted heteroaryl derivatives, compositions, and methods of use

This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. The compounds of Formula (I) may activate an erythropoietin receptor and thus, may be useful to induce red blood cell production. The compounds of Formula (I) and compositions including compounds of Formula (I) may be useful in a variety of applications including the management, treatment and/or control of diseases caused at least in part by deficient (or inefficient) EPO production relative to hemoglobin level.

Aryl and heteroaryl compounds, compositions and methods of use

This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. Compounds of Formula (I) may be useful for treating viral infections including orthopox viruses, either alone or in combination with other therapeutic agents.

Aryl and heteroaryl compounds, compositions, and methods of use

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Oak Ridge, NC, United States of America

Murty N Arimilli