University of the Sciences in Philadelphia

Murray Zanger

In accordance with the present invention, there is now provided novel anti-HIV compounds of the formulae selected from the group consisting of:

Diarylsulfone non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus

In accordance with the present invention, there is now provided novel anti-HIV compounds of the formulae selected from the group consisting of: ##STR1## wherein R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or halogen; R.sub.3 is hydrogen, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or halogen; R.sub.4 is hydrogen or halogen, R.sub.5 is hydrogen; C.sub.1 -C.sub.4 alkoxy, nitro, halogen or haloalkyl; R.sub.6 is hydrogen or nitro; R.sub.7 is hydrogen or C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, nitro or halogen; R.sub.8 is hydrogen, hydroxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or halogen; R.sub.9 is hydrogen or nitro; R.sub.10 is hydrogen or halogen; R.sub.11 is hydrogen, C.sub.1 -C.sub.4 amine; R.sub.12 is hydrogen, C.sub.1 -C.sub.4 alkyl or halogen; R.sub.13 is hydrogen, C.sub.1 -C.sub.4 amine; R.sub.14 is hydrogen or halogen; R.sub.15 is hydrogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl, nitro, or halogen; R.sub.16 is hydrogen or nitro; R.sub.17 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, nitro or halogen; R.sub.18 is hydrogen, C.sub.1 -C.sub.4 alkoxy, hydroxy, or halogen; R.sub.19 is hydrogen or nitro; and R.sub.20 is hydrogen or halogen and R.sub.21 is hydrogen or NO.sub.2, or a pharmaceutically acceptable salt thereof.

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Havertown, PA, United States of America

Murray Zanger