Inex Pharmaceuticals Corporation

The University of Texas System

Hana Biosciences, Inc.

Other

The University of British Columbia

Talon Therapeutics, Inc.

Murray S Webb

Patricia M Logan

Andreas H Sarris

Clive T R Burge

James H Goldie

Fernando Cabanillas

Marcel B Bally

Lawrence D Mayer

Thomas D Madden

James Jackson Miller

Paul G Tardi

Sean C Semple

Sandra K Klimuk

Lewis S Choi

Quet F Ahkong

Clive T Burge

This invention provides methods for treating neoplasias in a mammal. In particular, the invention provides methods for treating various types of lymphomas, including relapsed forms of non-Hodgkin's Lymphoma. These methods involve the administration of liposome-encapsulated vinca alkaloids, e.g., vincristine, to a mammal with a lymphoma.

Compositions and methods for treating lymphoma

This invention provides compositions and methods for treating neoplasias in a mammal. In particular, the invention provides liposome-encapsulated vinca alkaloids, e.g., vinorelbine, and methods of treating a mammal using such compositions.

Compositions and methods for treating cancer

The present invention provides a novel class of polyethylene glycol modified ceramide lipids. The lipids can be used to form liposomes optionally containing various biological agents or drugs, such as anti-cancer agents. In addition, methods of use for the liposomes are provided.

Polyethylene glycol modified ceramide lipids and liposome uses thereof

Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of ciprofloxacin, and alkaloid drugs, particularly swainsonine, vincristine and vinblastine, is significantly improved.

Sphingosomes for enhanced drug delivery

Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of lipophilic drugs such as the vinca alkaloids, and particularly vincristine and vinblastine, to tumors is significantly improved.

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Delta, Canada

Murray S Webb