Harbor Branch Oceanographic Institution, Inc.

Pharma Mar, S.a.

Murray H Munro

John W Blunt

Nigel B Perry

Dolores Garcia Gravalos

Robin J Lake

Marc S Litaudon

Andrew M Thompson

Halichondrin derivatives, isolatable from a marine sponge of the Lissodendoryx Sp., have cytotoxic preparations and are of the formula: ##STR1## wherein R.sup.1 and R.sup.2 together form a spiro attached ring system selected from the group consisting of: ##STR2##

Halichondrins

A new biologically active compound discorhabdin D, pharmaceutical compositions containing same, methods of producing the compound and compositions and methods of using them are disclosed. The new compound, discorhabdin D, has the structure: ##STR1##

Discorhabdin D, compositions containing same and methods of preparatio

Mycalamide compounds are derived from marine sponges of the genus Mycale or prepared by synthetic methods. These compounds and pharmaceutical compositions containing them as active ingredients are useful as antitumor and antiviral agents.

Mycalamide compounds, compositions thereof and methods of preparation

This invention relates to novel discorhabdin compositions which are useful as antitumor, antibacterial and antifungal compositions, a process of producing the compositions and a method for inhibiting tumors, bacteria and fungi utilizing the compositions. More particularly, the novel discorhabdin compositions are organic compounds which are derived from marine sponges genus Latrunculia.

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Christchurch, New Zealand

Murray H Munro