Centre National De La Recherche Scientifique

Universitè De Montpellier

Institut National De La Sante Et De La Recherche Medicale

Centre Hospitalier Universitaire De Montpellier

Ecole Nationale Superieure De Chimie De Montpellier (enscm)

Muriel Amblard-Caussil

Jean Martinez

Christian Jorgensen

Guillaume Laconde

Florence Apparailly-Sechan

Isabelle Duroux-Richard

The present invention relates to peptidomimetic macrocycles comprising at least one macrocycle-forming linker and an amino acid sequence chosen from the group consisting of: i) an amino acid sequence with at least about 50%, 60%, 70%, 80%, 90%, or 95% sequence identity to a human sequence IRAK2 54-71 (SEQ ID No1) and 100% identity with the amino acids in the positions 5-6, 9-11, 14-15 or ii) an amino acid sequence with at least about 50%, 60%, 70, 80%, 90%, or 95% sequence identity to a human sequence IRAKM 66-83 (SEQ ID No2) and 100% identity with the amino acids in the positions 5-6, 9-11, 13-14, wherein the peptidomimetic macrocycle comprises an a-helix and at least two natural or two non-natural amino acids crosslinked by a macrocycle-forming linker. It also concerns method of preparation of said peptidomimetic macrocycles and uses thereof, pharmaceutical composition and uses thereof, in particular as inhibitors of inflammatory pathways.

Stapled peptides and uses thereof

Growing community of inventors

Saint Vincent de Barbeyrargues, France

Muriel Amblard-Caussil