Imperial Chemical Industries Limited

Zeneca Limited

Murdoch A Eakin

Philip N Edwards

George R Brown

Michael S Large

Keith Blakeney Mallion

Peter W Caulkett

Geraint Jones

Peter John Harrison, Deceased

Barrington John Furr

Michael J Cooper

Justus Kenneth Landquist

Anthony J Hayter

Therapeutic amines

2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamide compounds are disclosed as useful in the treatment of obesity and related conditions. Processes for their preparation are described, as are novel intermediates and pharmaceutical compositions containing them.

Chemical compounds

Bisbiguanide compounds

This invention relates to indole derivatives which have anti-cancer activity. According to the invention there is provided an indole derivative of the formula I: ##STR1## in which X is an oxygen or sulphur atom, Ra is a phenyl radical which is optionally substituted by one or two groups selected from halogen atoms and 1-6C alkyl, 1-6C alkoxy and trifluoromethyl radicals and Rb is a hydrogen atom or a 2-6C alkoxycarbonyl radical. Manufacturing processes and pharmaceutical compositions are also described.

Amino, cyano phenylthio or phenoxyl indole derivatives

Salicylanilide derivatives bearing a 3-secondary or tertiary alkyl, 5-cyano, alkanoyl, phenylazo, phenylthio, phenylsulphinyl or phenylsulphonyl, an optional 6-methyl and a variety of substituents on the anilino ring. The compounds have anthelmintic activity especially against liver fluke.

Salicylanilide derivatives having anthelmintic activity

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Macclesfield, United Kingdom

Murdoch A Eakin