Transtech Pharma, Inc.

Vtv Therapeutics LLC

High Point Pharmaceuticals, LLC

Muralidhar Bondlela

Robert Carl Andrews

Adnan M M Mjalli

Devi Reddy Gohimukkula

Thomas Scott Yokum

Mohan Rao

Dharma Rao Polisetti

Mustafa Guzel

Jeff Jiqun Zhu

Stephen Thomas Davis

David R Jones

Kalpathy Chidambareswaran Santhosh

Suparna Gupta

Daniel Peter Christen

Christopher Behme

Anitha Hari

Jeremy T Cooper

Raju Bore Gowda

Ghassan Qabaja

William Kenneth Banner

Jennifer L R Freeman

Ravindra Reddy Yarragunta

Pingzhen Wang

Kurt Sundermann

James C Quada, Jr

Guoxiang Huang

Rongyuan Xie

Murty N Arimilli

Bapu Reddy Gaddam

Ramesh Gopalaswamy

Tan Ren

Xiao-Chuan Guo

Rajashaker Kache

Santhosh Kalpathy

Suvi Simila

Eugene Campian

James Quada

Jennifer LR Freeman

Adnan MM Mjalli

David Jones

Daniel P Christen

The present invention relates to substituted azoanthracene derivatives and intermediates for the preparation thereof. The substituted azoanthracene derivatives and associated intermediates may be useful for the preparation of pharmaceutical compositions for the treatment or prevention of diseases, disorders, and conditions wherein modulation of the human GLP-1 receptor is beneficial.

Substituted azoanthracene derivatives and intermediates for preparation thereof

The invention provides novel phenylglyoxylic acid derivatives, which may be useful as intermediates for preparing stereoisomerically enriched drug compounds. The invention also provides methods of making phenylglyoxylic acid derivatives, and uses of phenylglyoxylic acid derivatives.

Phenylglyoxylic acid derivatives and their preparation and use

The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof These compounds are useful in the treatment of RAGE-mediated diseases. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.

Phenyl-heteroaryl derivatives and methods of use thereof

The present invention is directed to substituted azoanthracene derivatives or pharmaceutically acceptable salts thereof that modulate the human GLP-1 receptor and that may be useful in the treatment of diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial, such as diabetes mellitus type 2. The invention is also directed to pharmaceutical compositions comprising these compounds and to the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation of the human GLP-1 receptor is beneficial.

Substituted azoanthracene derivatives, pharmaceutical compositions, and methods of use thereof

The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.

Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.

Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use

This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. The compounds of Formula (I) may activate an erythropoietin receptor and thus, may be useful to induce red blood cell production. The compounds of Formula (I) and compositions including compounds of Formula (I) may be useful in a variety of applications including the management, treatment and/or control of diseases caused at least in part by deficient (or inefficient) EPO production relative to hemoglobin level.

Aryl and heteroaryl compounds, compositions and methods of use

This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. Compounds of Formula (I) may be useful for treating viral infections including orthopox viruses, either alone or in combination with other therapeutic agents.

Aryl and heteroaryl compounds, compositions, and methods of use

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Greensboro, NC, United States of America

Muralidhar Bondlela