Bristol-Myers Squibb Compnay

Murali T G Dhar

Jingwu Duan

Hai-Yun Xiao

Andrew J Tebben

Stephen T Wrobleski

Bin Jiang

Zhonghui Lu

Shuqun Lin

Gregory D Brown

Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: &#x2014;(CR3R3)2-5-, &#x2014;(CR3R3)x-Y&#x2014;(CR3R3)y-, &#x2014;Y&#x2014;(CR3R3)2-3-Y&#x2014;, &#x2014;CR3R3-Y&#x2014;(CR3R3)2-Y&#x2014;, &#x2014;Y&#x2014;(CR3R3)2-Y&#x2014;CR3R3-; and Y, R1, R2, R3, R5, R6, R8, x, and y are define herein. Also disclosed are methods of using such compounds as modulators of TNF&#x3b1;, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Tricyclic heterocyclic compounds useful as inhibitors of TNF

Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: (i) &#x2014;(CRR)&#x2014;; (ii) &#x2014;(CRR)&#x2014;Y&#x2014;(CRR)&#x2014;; Or (iii) &#x2014;Y&#x2014;(CRR)&#x2014;Y&#x2014;; and Y, R, R, R, R, R, R, x, and y are defined herein. Also disclosed are methods of using such compounds as modulators of TNF&#x3b1;, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Substituted tricyclic heterocyclic compounds

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Newtown, PA, United States of America

Murali T G Dhar