National Institutes of Health, a Component of the US Dept. of Health & Human Services

General Electric Company

Wake Forest University

H. Lee Moffitt Cancer Center and Research Institute, Inc.

Murali Krishna Cherukuri

James B Mitchell

Nallathamby Devasahayam

Sankaran Subramanian

Angelo Russo

Shingo Matsumoto

Janusz Koscielniak

John A Cook

Robert J Gillies

David A Wink

S Bruce King

Jonathan Alan Murray

W Marston Linehan

Frank S Harrington

Jan Henrik Ardenkjaer-Larsen

Rolf G Tschudin

Ramachandran Murugesan

Timothy William Skloss

Marcelino Bernardo

Keita Saito

Anne Marie DeLuca

Wilmarie Flores-Santana

Mobae Afeworki

Kazutoshi Yamamoto

Jeffrey R Brender

Shun Kishimoto

Tracey A Rouault

Jeeva P Munasinghe

Hellmut Merkle

Jan Henrik Ardenkjaer Larsen

Kinetic monitoring of in vivo metabolism of labelled tracers is based on singular value decomposition or Tucker Decomposition of magnetic resonance spectral image data. Data decomposition is used in conjunction with rank reduction to improve signal-to-noise ratio. Rank reduction can be applied in one or more of a spectral, spatial, or temporal dimension. Rank is generally reduced based on a number of expected analytes/metabolites or fit of measured data to a model.

Denoising of dynamic resonance spectroscopic imaging using low rank approximations in the kinetic domain

A system and method for transporting a hyperpolarized substance is disclosed. A transport vessel for transporting such a hyperpolarized substance includes a vessel housing, a chamber formed within the vessel housing that is configured to receive a container holding a hyperpolarized substance, and an electromagnet configured to generate a magnetic containment field about the chamber when a current is supplied thereto, the magnetic containment field comprising a homogeneous magnetic field. The transport vessel also includes a non-magnetic power source to supply the current to the electromagnet and a control circuit configured to selectively interrupt the supply of current to the electromagnet so as to control generation of the magnetic containment field, with the transport vessel being magnetically inert when the supply of current to the electromagnet is interrupted by the control circuit.

Hyperpolarized media transport vessel

The identification of pOlowering agents as transient hypoxia-inducers is disclosed herein. Provided is a method of enhancing the efficacy of a hypoxia-sensitive agent in a subject, by administering to the subject a therapeutically effective amount of the hypoxia-sensitive agent and a therapeutically effective amount of a pOlowering agent. Methods of treating a subject with a tumor, by administering to the subject a therapeutically effective amount of a pOlowering agent and a therapeutically effective amount of a hypoxia-sensitive agent are also disclosed.

Use of pyruvate or succinate to enhance the efficacy of a hypoxia activated prodrug for the treatment of tumors

Disclosed are nitroxide modified NSAID compounds of the formula (I) or a pharmaceutically acceptable salt or enantiomer thereof:  in which R, R, R, R, R, R, R, R, R, R, R, and n are defined herein and pharmaceutical compositions thereof. Further disclosed is a method of treating or preventing various disorders, such as inflammation, cancer, diabetes, a cardiovascular disorder, weight gain, polyps, and/or chronic pain, in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt or enantiomer of formula (I). A method of imaging the compound or pharmaceutically acceptable salt or enantiomer of formula (I) in the body of the animal is also provided.

Nitroxide modified non-steroidal anti-inflammatory compounds and uses thereof in the treatment and prevention of diseases or disorders

The invention provides therapeutic methods that include administering a stable nitroxide to a subject that has, is suspected to have, or is at risk for having a condition associated with reduced VHL or elevated HIF-2&#x3b1;.

Nitroxide therapy for the treatment of von Hippel&#x2014;Lindau disease (VHL) and renal clear cell carcinoma (RCC)

An echo-based single point imaging (ESPI) system () providing high-resolution oxygen images of a sample is disclosed. The ESPI system () employs spin echo detection of the resonance from a spin probe and concurrent Single Point Imaging (SPI) for spatial encoding of the oxygen concentration within the sample. Images are derived by comparing spin echo intensities of two images reconstructed at two time points selected at identical time intervals on either side of a refocusing pulse, eliminating artifacts associated with sample magnetic susceptibility and field inhomogeneity effects.

Quantitative oxygen imaging systems and methods using echo-based single point imaging

An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for processing the signal data, using means including a digital signal processor.

Fast electron paramagnetic resonance imaging (EPRI) using CW EPR spectrometer with sinusoidal rapid-scan and digital signal processing

An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for transmitting, receiving and processing the signal data, using means including a digital signal processor.

Fast electron paramagnetic resonance imaging (EPRI) in the CW EPR mode using rapid-scan in the presence of rotating gradients and direct detection with transmit/receive and data processing in a digital signal processing platform

The present invention provides a method for the prophylactic and therapeutic treatment of cancer. The method comprises administering to an animal, preferably a mammal, more preferably a human, at risk for developing a cancer or having a cancer a nitroxide or a prodrug thereof, wherein the nitroxide or prodrug thereof preferably is alicyclic or heterocyclic and more preferably is a compound of Formula (I) or Formula (II): in an amount sufficient to prevent or treat said cancer, wherein said cancer is susceptible to prevention or treatment by said nitroxide or prodrug thereof. Also provided is a composition for use in the method 

Use of tempol for the treatment of Li-Fraumeni syndrome and ataxia telangiectasia

A radiofrequency (RF) coil design, suitable for detecting time domain electron paramagnetic resonance (EPR) responses from spin probes after pulsed excitation using radiofrequency irradiation (60-400 MHz), is configured in an array of numerous surface coils of appropriate diameters connected in a parallel or axial configuration with appropriate spacing between individual surface coils to form a volume type resonator.

Resonant structure for spatial and spectral-spatial imaging of free radical spin probes using radiofrequency time domain electron paramagnetic resonance spectroscopy

Growing community of inventors

Potomac, MD, United States of America

Murali Krishna Cherukuri