The United States of America As Represented by the Department of Health

The United States of America As Represented by the Dept. of Health &

Murali K Cherukuri

James B Mitchell

Sankaran Subramanian

Rolf G Tschudin

Ramachandran Murugesan

Mark S Mirotznik

Bradley Allen Roth

Paul G Zablocky

John Bourg

Paul D Smith

Thomas J Pohida

Walter S Friauf

A system for performing pulsed RF FT EPR spectroscopy and imaging includes an ultra-fast excitation subsystem and an ultra-fast data acquisition subsystem. Additionally, method for measuring and imaging in vivo oxygen and free radicals or for performing RF FT EPR spectroscopy utilizes short RF excitations pulses and ultra-fast sampling, digitizing, and summing steps.

In vivo imaging and oxymetry by pulsed radiofrequency paramagnetic

A gated RF preamplifier used in system for performing pulsed RF FT EPR spectroscopy and imaging or MRI. The RF preamplifier does not overload during a transmit cycle so that recovery is very fast to provide for ultra-fast data acquisition in an ultra-fast excitation subsystem. The preamplifier includes multiple low-gain amplification stages with high-speed RF gates inserted between stages that are switched off to prevent each stage from overloading during the transmit cycle.

Gated RF preamplifier for use in pulsed radiofrequency electron

System and method for performing in vivo imaging and oxymetry and FT

An EPR imager and spectrometer includes pulse generating system for generating broadband pulses having an RF carrier frequency that is not highly absorbed by biological samples. The pulse generating system includes up and down chirp convertors for frequency modulating a carrier frequency pulse and compressing the frequency modulated pulse to form a broadband excitation pulse of high energy. Such a machine could form the basis of a clinical imaging device capable of high sensitivity to free radical species in human patients.

Pulsed low frequency EPR spectrometer and imager

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Rockville, MD, United States of America

Murali K Cherukuri