Sierra Sciences, Inc.

Munirathnam Chaguturu

William H Andrews

Federico C A Gaeta

Hamid Mohammadpour

Laura A Briggs

Mieczyslaw A Piatyszek

Lancer K Brown

Christopher A Foster

Jian Zhang

October Pawlik

Tom Kerley

Jessica Wheeler

Penelope Burke

Beril Karakas

Telomerase reverse transcriptase (TERT) expression enhancing compounds, and methods for using the same, are provided. In some embodiments, the compounds are azoles, such as such as pyrazoles, imidazoles, triazoles, tetrazoles, thiazoles, isothiazoles, oxazoles, and isoxazoles. In certain embodiments, the azole compound includes an acyl substituent which includes an amide, for example, an alkyl amide. Methods of interest include contacting cells with a TERT expression enhancing effective amount of compound to increase TERT expression in the cells. These compounds and methods find use in a variety of applications in which increased expression of telomerase reverse transcriptase is desired.

Telomerase reverse transcriptase (TERT) expression enhancing compounds and methods for using the same

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Lawrence, KS, United States of America

Munirathnam Chaguturu