Toyama Chemical Co., Ltd.

Fujifilm Corporation

Taisho Pharmaceutical Co., Ltd.

Fujifilm Toyama Chemical Co., Ltd.

Muneo Shoji

Masato Takahashi

Hiroki Urabe

Tetsuya Yabuuchi

Hajime Takashima

Yusuke Oka

Hironori Kotsubo

Fumito Uneuchi

Kentaro Furuya

Yasuko Kawaguchi

Risa Tsuruta

Kei Matsuura

Yoichiro Suga

Tetsuya Matsushita

Hirofumi Omura

Naoko Yasobu

Naomi Sugaya

Hiromi Hayashi

Tomofumi Nakae

An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. A compound represented by General Formula [1](the reference signs in Formula have the same definitions as those described in the present specification) or a salt thereof has strong antibacterial activity against Gram-negative bacteria such asand drug-resistant Gram-negative bacteria including multidrug-resistant, and the pharmaceutical composition containing the compound or a salt thereof is useful as an antibacterial agent.

Penam derivative or salt thereof, pharmaceutical composition, and applications thereof

An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. According to the present invention, a compound represented by General Formula [1] (the reference signs in the formula have the same definitions as those described in the present specification) or a salt thereof has strong antibacterial activity against Gram-negative bacteria such asand drug-resistant Gram-negative bacteria including multidrug-resistant, and the pharmaceutical composition containing the compound or a salt thereof is useful as an antibacterial agent. 

2-carboxypenam compound or salt thereof, pharmaceutical composition containing novel 2-carboxypenam compound or salt thereof, and applications thereof

A compound represented by general formula (1) (wherein Rrepresents a hydrogen atom, an optionally substituted Calkyl group or the like; Rrepresents a hydrogen atom, an optionally substituted Calkyl group or the like; Rrepresents a hydrogen atom or an optionally substituted Calkyl group; Rrepresents a hydrogen atom, an optionally substituted Calkyl group or the like; Xrepresents an optionally substituted Calkynylene group or the like; A represents an optionally substituted bivalent aromatic hydrocarbon group or the like; Xrepresents an optionally substituted Calkylene group or the like; Yrepresents an oxygen atom or the like; and Rrepresents a hydrogen atom or the like) or a salt thereof is useful as an antibacterial agent. 

Hydroxamic acid derivative or salt thereof

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria includingand its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof. 

Hydroxamic acid derivative

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria includingand its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof: 

Growing community of inventors

Toyama, Japan

Muneo Shoji