Yamanouchi Pharmaceutical Company Ltd.

Muneo Fukui

Atsushi Kajiyama

Kazuhiro Sako

Shunsuke Watanabe

Masayoshi Aruga

Tadayoshi Ohmura

Hitoshi Kawai

Toyohiro Sawada

Hiroshi Sugiura

Satoru Yoneya

Akira Okada

Masataka Katsuma

Hiroshi Nakashima

Toshiharu Hosono

Yukio Kubota

Hiroitsu Kawata

Takao Mizumoto

Yutaka Konno

Yoshinori Masuda

Saburo Higuchi

Yoshiaki Soeishi

Tamio Hikosaka

Shigeru Masuyama

Kouji Tomuro

The invention provides a hydrogen-type sustained-release preparation comprising (1) at least one drug, (2) an additive which insures a penetration of water into the core of the preparation and (3) a hydrogen-forming polymer, wherein said preparation is capable of undergoing substantially complete gelation during its stay in the upper digestive tract such as stomach and small intestine and is capable of releasing the drug in the lower digestive tract including colon. By the preparation of the invention, the drug is efficiently released and absorbed even in the colon so that a steady and sustained release effect can be achieved.

Hydrogel-forming sustained-release preparation

Colon-specific drug release system

Intrabuccally dissolving compressed moldings comprising a saccharide having low moldability having been granulated with a saccharide having high moldability. The moldings of the present invention show quick disintegration and dissolution in the buccal cavity and have an adequate hardness.

Intrabuccally dissolving compressed moldings and production process

A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ratio, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).

Drug release controlling coating material for long acting formulations

A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ration, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).

Drug-release controlling coating material for long acting formulations

A pharmaceutical controlled-release individual unit or multiple units formulation in which the individual unit comprises a granulation product obtained by adding a release controlling agent to a mixture of a physiologically active substance and units-forming substance(s) and granulating and resultant mixture, said granulation product (granules) being substantially not disintegrated but gradually releasing the physiologically active substance in the gastrointestinal tract.

Controlled-release multiple units pharmaceutical formulation

A solid microdose drug preparation containing a microdose drug such as formoterol fumarate or .beta.-methyldigoxin coated with wax. In the drug preparation, the stability and the content uniformity of the microdose drug have been improved.

Solid drug preparations

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Shizuoka, Japan

Muneo Fukui