Zenyaku Kogyo Kabushiki Kaisha

Muneaki Takase

Kimitomo Yoshioka

Hiroaki Yamazaki

Toshiharu Narita

Jun-Chao Cai

Shigeru Abe

Toshihiko Komatsu

Susumu Mitsuhashi

Den-ichi Mizuno

Hiroshi Mitsuhashi

Koji Hayashi

Ichiro Washizawa

Sosuke Yasui

Takashi Iwaki

Toshiyuki Matsuno

Kenichi Saito

Akihisa Miyakawa

Tadahiro Nakamura

Toshiyuki Takezawa

Kazuo Kamiya

Water soluble bis-dioxopiperazine derivatives

1-azaindolizine derivatives, synthetic intermediates thereof and

Bis-dioxopiperazine derivatives and pharmaceutical compositions

Bis-dioxopiperazine derivatives

A thiazole derivative represented by the formula I, pharmaceutically acceptable acid addition salt thereof, and a process for preparation thereof ##STR1## wherein R.sub.1 represents --COOR.sub.4, ##STR2## or cyano wherein R.sub.4 represents hydrogen or lower alkyl, and

Thiazole derivatives and medical compositions thereof

1,4-thiazine derivative, and cardiotonic agent comprising it as

Disclosed are novel bis-dioxopiperazine derivatives and non-toxic salts thereof, process for their preparation, antitumor agents comprising them and compositions containing them. The bis-dioxopiperazine derivatives are represented by the following general formula (I): ##STR1## wherein R represents an alkyl radical having 1 to 17 carbon atoms, a cycloalkyl radical having 3 to 7 carbon atoms, a lower alkyl radical having a substituent or substituents selected from the group consisting of halogeno, carboxy, alkoxycarbonyl having 2 to 5 carbon atoms, lower alkoxy, substituted or unsubstituted phenoxy, naphthyloxy, substituted or unsubstituted phenylthio, substituted or unsubstituted phenyl and naphthyl, a substituted or unsubstituted phenyl lower alkenyl radical, a substituted or unsubstituted phenyl radical, a naphthyl radical, a heterocyclic radical selected from the group consisting of pyridyl, furyl and thienyl, an alkoxy radical having 1 to 8 carbon atoms, a substituted or unsubstituted phenyl lower alkoxy radical, or a substituted or unsubstituted phenoxy radical. A substituent or substituents on R may be selected from the group consisting of lower alkyl, halogeno, lower alkoxy, acyloxy having 2 to 5 carbon atoms, methylenedioxy, carboxy, amino, methanesulfonylamino and nitro. The above-mentioned 'lower alkyl', 'lower alkoxy' and 'lower alkenyl' respectively refer to alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms and alkenyl having 2 to 4 carbon atoms.

Bis-dioxopiperazine derivatives, process for their preparation,

Disclosed is a novel 1,4-thiazine derivatives represented by the following general formula I and a pharmaceutically acceptable acid addition salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 respectively represent a hydrogen atom or a lower alkyl group. Also disclosed are processes for preparation of a novel thiazine derivative represented by the general formula I, which comprise reacting a compound of the general formula III with a compound of the general formula A-X' in a compound containing a pyridinyl group as a solvent to obtain a compound of the general formula II: ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined above, A represents a group ##STR3## in which X represents a halogen atom and n is a number of 1 to 3, and X' represents a halogen atom which may be the same as or different from X, and reacting the compound of the general formula II with sulfur at elevated temperature or stirring the compound of the general formula II in a solution system comprising zinc and a carboxylic acid. Further disclosed is a cardiotonic agent comprising a pharmaceutically acceptable excipient and, as the active component thereof, an effective amount of the novel 1,4-thiazine derivative having the general formula I.

1,4-Thiazine derivatives

Polysaccharide PS-A obtained from barrenwort deriving from plants

The present invention provides an extract obtained by extracting a plant belonging to the genus Epimedium sp. with a mixed solvent of water and a water-miscible organic solvent or with water, defatting the obtained aqueous extract and collecting a high-molecular compounds-containing fraction from the defatted aqueous extract, a process for preparation of this extract, an antibacterial agent comprising this extract as an effective component and an antibacterial therapy by using this extract.

Extract from barrenwort

Condurango glycoside compounds, processes for their preparation,

There is provided a process for production of o-(2,6-dichloroanilino)phenylacetic acid or a salt thereof by reacting o-chlorophenylacetic acid or an alkali metal salt thereof with 2,6-dichloroaniline in the presence of a base and at least 0.5 mol of a copper catalyst per mol of o-chlorophenylacetic acid in a polar solvent.

Process for production of o-(2,6-dichloroanilino)-phenylacetic acid

New extracts of Marsdenia cundurango Reichenbach fil., processes for preparing them, antitumor agents comprising them, compositions containing them and methods of treating tumor with them are described herein in which the extracts consist essentially of the portion of Marsdenia cundurango Reichenbach fil. which is soluble in lower alcohols and in chlorinated hydrocarbons other than carbon tetrachloride and insoluble in carbon tetrachloride or aromatic hydrocarbons.

Extracts of Marsdenia cundurango Reichenbach fil

A coating apparatus for manufacturing of solid particles with digestive tracts-soluble film by rolling water-containing solid particles at high speed, adding a coating liquid and drying them simultaneously. Particles are disposed in a generally annular volume and supported on a generally rotary disk which is closely confined within a fixed cylinder and closely spaced from an inner fixed cylinder; said cylinder forming said annular volume. Partition means adjustably spaced from said plate, divide said volume into separate coating, water feed and drying chambers. The partitions form a sealing relationship with the particles.

Tumbing apparatus

A coating process and apparatus for manufacturing of solid particles with digestive tracts-soluble film by rolling water-containing solid particles at high speed, adding a coating liquid and drying them simultaneously.

Process for coating solid particles with a digestive tract-soluble film

Growing community of inventors

Tokyo, Japan

Muneaki Takase