United Therapeutics Corporation

Decode Genetics Ehf

Oncquest, Inc.

Munagala Rao

Robert M Moriarty

Raju A Penmasta

Liang Guo

James P Staszewski

Mark E Gurney

Vincent Premaratna Sandanayaka

Jasbir Singh

Alexander Kiselyov

Alex Burgin

Rajendra G Mehta

The invention relates to substituted benzothiazoles, benzoxazoles&#x2014;and their counterparts having pyridine and pyrimidine rings replacing the benzene ring&#x2014;that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles. A particular embodiment is 

Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and CNS disorders

A compound of formula I:wherein R1 is hydrogen, R2 is &#x2014;CH, R3 is &#x2014;CH, and R4 is hydrogen, useful in cancer prevention and therapy.

1&#x3b1;-Hydroxyvitamin D5, its synthesis and use in cancer prevention

An improved method is described for making 9-deoxy-PGF -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. The invention also relates to novel intermediates prepared during the synthesis of the 9-deoxy-PGF -type compounds.

Process for stereoselective synthesis of prostacyclin derivatives

An improved method is described for making 9-deoxy-PGF -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.

Prostacyclin derivatives

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Westmont, IL, United States of America

Munagala Rao