Korea Research Institute of Bioscience and Biotechnology

Mun Chual Rho

Soyoung Lee

Young Min Kim

Seung Jae Lee

So Young Lee

Woo Song Lee

Young Bae Ryu

Seung Woong Lee

Su Jin Park

Yu Jeong Jeong

Cha Young Kim

Jae Cheol Jeong

Suk Weon Kim

Kwon Moo Park

Chan Sun Park

Kyoung Oh Cho

Sang-Hyun Kim

Mi Hye Park

Kyungsook Jung

Ji Hak Jeong

Jong Sun Chang

Hyun Mee Oh

Keug Hyun Ahn

Kyung Sook Jung

Sang Hyun Kim

The present invention relates to a composition for preventing, improving or treating drug-induced nephrotoxicity, the composition comprising oleanolic acid acetate as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating drug-induced nephrotoxicity comprising oleanolic acid acetate or a pharmaceutically acceptable salt thereof as an active ingredient, a health functional food for preventing or improving drug-induced nephrotoxicity comprising the active ingredients, and an anticancer adjuvant comprising the active ingredients. The oleanolic acid acetate of the present invention is derived from a natural product and has no side effects and no cytotoxicity and has excellent effects of preventing, improving and treating nephrotoxicity caused by a drug, particularly a platinum-based anticancer drug, so that it can be utilized as a pharmaceutical composition, a health functional food, and a cancer adjuvant thereof.

Composition comprising oleanolic acid acetate as active ingredient for preventing, alleviating, or treating renal toxicity induced by medicine

The present invention relates to a method for mass-production of viniferin using stevioside from cell culture of grape tree tissue. Viniferin is known to be effective for protection of liver, anticancer, antioxidant, and skin whitening, have an effect of inhibiting oxidation of low-density lipoprotein and high-density lipoprotein and inhibiting the proliferation and migration of vascular smooth muscle cells. Therefore, the present invention is very useful for the mass production of viniferin among the useful substances (stilbene compounds) from a callus derived from the anther tissue of the grape plant, which is very important for the related industries.

Method for mass-producing viniferin using stevioside from cell culture of grapevine tissue

The present invention relates to a composition for enhancing immunity through inducing the expression of interferon-&#x3b2; comprising a compound represented by Formulas 1 to 8, orextract comprising the same and fractions thereof as an active ingredient, a feed additive, feed composition, pharmaceutical composition, food composition, and over-the-counter (OTC) drug composition comprising the composition, and a method for enhancing immunity through administrating the composition. A composition for inducing the expression of interferon-&#x3b2;, comprising a compound represented by Formulas 1 to 8 of the present invention,extract comprising the same, or fractions thereof as active ingredient can prevent, alleviate, or treat the diseases that can be prevented or treated by increasing the expression of interferon.

Composition for enhancing immunity containing compounds represented by chemical formulas 1-8 or sophora flavescens extract as active ingredient

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Daejeon, South Korea

Mun Chual Rho