Korea Research Institute of Bioscience and Biotechnology

Mun-Chual Rho

Kyeong Seok Lee

Young Kook Kim

Su-Jin Park

Chul-Ho Lee

Jung Joon Lee

Woo-Song Lee

Hyung-Jae Jeong

Jae Sun Moon

Sung Uk Kim

Yongseok Choi

Hyun Sun Lee

Hyung-Jun Kwon

Young-Bae Ryu

Jeong Hyung Lee

Hye-Ran Park

Sung Eun Kim

Young-Min Kim

Sang Han Lee

Yun Mi Lee

Tae Sook Jeong

Sangku Lee

Young Soo Hong

Tae Hoon Kang

Ki Duk Park

Won Shik Choi

Jong-Sun Chang

Mal-Sun Shin

Ju Ryoung Kim

Eui Il Hwang

The present invention relates to a complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof, and relates to a pharmaceutical composition for preventing or treating an influenza virus infection comprising the complex as an active ingredient. Also, the present invention relates to a food composition for preventing or improving an influenza virus infection, a virucidal quasi-drug composition, a virucidal feed additive, and a feed, which comprises the complex as an active ingredient. According to the present invention, the complex comprising a compound of formula (I), or a plant extract comprising the compound or a fraction thereof; and stevioside, or a plant extract comprising the stevioside or a fraction thereof exhibits a virucidal effect and an effect of inhibiting cell degradation against an influenza virus as well as antiviral efficacy in a specific pathogen-free (SPF) chicken, and thus can be usefully used in the prevention and treatment of an influenza virus infection.

Curcuminoid-based compound/stevioside-containing complex for the prevention and treatment of an influenza virus infection

Disclosed is a composition comprising a turmeric extract for preventing and treating influenza virus infection and for inhibiting neuraminidase activity. A turmeric extract, its fraction, and a curcuminoid-based compound separated therefrom may inhibit neuraminidase activity and have antiviral and cell degeneration inhibitory effects on influenza virus, and may be useful in preventing and treating influenza virus infection.

Composition for the prevention and treatment of influenza virus infection and composition for suppressing neuraminidase activity comprising turmeric extract

Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.

Method for the treatment of metabolic disorder containing benzazole derivatives as an active ingredient

Disclosed are indole derivatives, a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.

Indol derivatives, the method for preparing thereof and composition for the prevention and treatment of metabolic disorder containing the same as an active ingredient

The present invention relates to a pharmaceutical composition and health food comprisingsp. PL3 extract or phellinsin A isolated from the same as an effective component. More particularly, the present invention relates to a pharmaceutical composition and health food comprisingsp. PL3 extract or phellinsin A isolated from the same as an effective component, wherein thesp. PL3 extract and its phellinsin A inhibit the oxidation of low density lipoprotein (LDL), and further, they can be used as a component for medicine and food to effectively prevent and treat cardiovascular diseases such as hyperlipemia and arteriosclerosis.

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A fungicidal composition for agricultural use, containingextract or a sesquiterpene compound separated fromextract as an active ingredient, the composition having a antifungal activity against phytopathogenic fungi.

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Daejeon, South Korea

Mun-Chual Rho