Boston University

Muhammad Zaman

Ray Glynn Holt

Andrew J Acevedo

Darash Desai

Systems, devices, and methods for kinetic release testing of compounds are discussed herein. Ultrasonic agitation, with resultant cavitation and acoustic streaming, is used to breakdown and release drugs from one or more compounds to form a solution. The system uses small volumes of solvent to increase accessibility and portability of the system. Once dissolved, the solution is passed to a sampling system for calculating kinetic release behavior. The kinetic release behavior can be compared to existing reference data to identify the compound and/or confirm accurate manufacture by comparison of dissolution characteristics of the active ingredients. In some embodiments, streak photography and hydrophone measurements are used to study the effects of system parameters on the acousto-hydrodynamic environment.

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Sharon, MA, United States of America

Muhammad Zaman