University of California

Massachusetts Institute of Technology

Muhammad Omar Din

Jeff Hasty

Sangeeta N Bhatia

Lev S Tsimring

Tal Danino

Arthur Prindle

Michael Julius Liao

Sangeeta Bhatia

Lev Tsimring

Provided herein are multi-strain population control systems, methods, kits, and compositions. Also provided are methods, systems, kits, and compositions for culturing bacterial cells in multi-strain ecosystems, and temporally arranged multi-strain ecosystems or cultures using a synchronized lysis circuit in combination with multiple toxin/antitoxin systems to cycle continuously over a long period of time.

Multistrain population control systems and methods

Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide. In some embodiments, the therapeutic polypeptide kills tumor cells or which inhibits the growth of tumor cells.

Engineered bacteria for production and release of therapeutics

Growing community of inventors

San Diego, CA, United States of America

Muhammad Omar Din