King Fahd University of Petroleum and Minerals

King Abdulaziz City for Science and Technology

Muhammad Monim-Ul-Mehboob

Anvarhusein Abdulkadir Isab

Muhammad Altaf

Adam Ahmed Abdallah Seliman

Mohammed Ismail Wazeer

Saleh Abdulaziz Altuwaijri

Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be monodentate or bidentate and at least one dithiocarbamate-based ligand that is monodentate. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.

Gold(I) complexes with anticancer properties and methods of use thereof

Gold(I) complexes of formulae [Au{P(t-Bu)}(SCN(CH))] (1), and [Au{P(t-Bu)}(SCN(CH))] (2) have been prepared by the reaction of equimolar amounts of [Au{P(t-Bu)}(Cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry. These gold(I) dithiocarbamate complexes show in vitro cytotoxic activities against A549 (human lung carcinoma), HeLa (human cervical cancer) and MCF7 (human breast cancer) cell lines.

Treatment of cervical cancer with gold(I) complexes

Gold(I) complexes with t-butyl phosphine and dialkyl dithiocarbamate ligands

Growing community of inventors

Dhahran, Saudi Arabia

Muhammad Monim-Ul-Mehboob